PKM2 controls the degranulation of secondary and tertiary granules in neutrophils by phosphorylating SNAP-23  

作　　者：Xinlei Sun Dong Wang Yan Wang Lei Ye Fujie Shi Shuang Qu Hongwei Liang Ke Zen 

机构地区：[1]School of Life Science and Technology,China Pharmaceutical University,Nanjing,Jiangsu,China [2]Department of Pharmacology,School of Pharmacy,China Pharmaceutical University,Nanjing,Jiangsu,China [3]School of Life Sciences,Nanjing University,Nanjing,Jiangsu,China [4]Department of Gastroenterology and Hepatology,Jinling Hospital,Medical School of Nanjing University,Nanjing,China

出　　处：《Cellular & Molecular Immunology》2021年第8期2048-2050,共3页中国免疫学杂志（英文版）

基　　金：This work was supported by grants from the Ministry of Science and Technology of China(2018YFA0507100);the National Natural Science Foundation of China(31670917,31770981,32000634,and 81803626);the Natural Science Foundation of Jiangsu Province(BK20180556);the fellowship of China Postdoctoral Science Foundation(2018M630642).

摘　　要：Polymorphonuclear neutrophils(PMNs)possess multiple distinct types of cytoplasmic granules:secondary granules,tertiary granules,and azurophil granules[1].It has been suggested that PMN degranulation is controlled by exocytotic machinery comprising membrane-specific SNARE proteins,soluble N-ethylmaleimide sensitive factor(NSF)and soluble NSF-attaching proteins[2].

关 键 词：PKM2 NEUTROPHILS TERTIARY 

分 类 号：R392[医药卫生—免疫学]