血管内皮生长因子、乳酸脱氢酶和β_(2)-微球蛋白在急性白血病诊断及预后中的价值  

Value of vascular endothelial growth factor,lactate dehydrogenase and β_(2)-microglobulin in diagnosis and prognosis of acute leukemia

作　　者：李云[1] 段相会 朱映霞[1] 李苗 黄丽珍[1] 符美华[1] LI Yun;DUAN Xiang-hui;ZHU Ying-xia(Qinzhou First People’s Hospital,Qinzhou 535000,China)

机构地区：[1]广西壮族自治区钦州市第一人民医院,535000

出　　处：《中国实用医药》2021年第31期26-29,共4页China Practical Medicine

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(项目编号:E20180258)。

摘　　要：目的 探讨血管内皮生长因子(VEGF)、乳酸脱氢酶(LDH)、β_(2)-微球蛋白(β_(2)-MG)应用于急性白血病诊断和预后中的价值。方法 55例急性白血病患者作为观察组,55例健康体检者作为对照组,将观察组又分为化疗缓解组(35例)及未缓解组(20例)。对比化疗缓解组和未缓解组患者治疗前后及对照组的VEGF、LDH、β_(2)-MG水平,判断其在诊断急性白血病及判断预后中的价值。结果 化疗缓解组和未缓解组治疗前后的VEGF、LDH水平均高于对照组,化疗缓解组治疗前后的VEGF、LDH水平均低于未缓解组,化疗缓解组治疗后的VEGF、LDH水平低于本组治疗前,差异具有统计学意义(P<0.05);未缓解组治疗前后的VEGF、LDH水平对比,差异无统计学意义(P>0.05)。化疗缓解组和未缓解组治疗前后的β_(2)-MG水平均高于对照组,化疗缓解组治疗后的β_(2)-MG(2.51±0.48)mg/L低于本组治疗前的(3.85±0.85)mg/L及未缓解组治疗后的(3.28±0.25)mg/L,差异具有统计学意义(P<0.05);化疗缓解组和未缓解组治疗前及未缓解组治疗前后的β_(2)-MG水平对比,差异无统计学意义(P>0.05)。结论 VEGF、LDH及β_(2)-MG水平与急性白血病的诊断及预后息息相关,能够反映患者体内的肿瘤负荷情况,具有一定的临床意义。Objective To discuss the value of vascular endothelial growth factor,lactate dehydrogenase andβ_(2)-microglobulin in diagnosis and prognosis of acute leukemia.Methods 55 patients with acute leukemia were taken as the observation group,and 55 healthy subjects were taken as the control group.The observation group was divided into chemotherapy remission group(35 cases)and non-remission group(20 cases).The levels of VEGF,LDH and β_(2)-MG in the chemotherapy remission group and non-remission group before and after treatment and in the control group were compared to determine their value in diagnosing acute leukemia and determining prognosis.Results VEGF and LDH levels before and after treatment in the chemotherapy remission group and the non-remission group were higher than those in the control group;VEGF and LDH levels before and after treatment in the chemotherapy remission group were lower than those in the non-remission group;VEGF and LDH levels in the chemotherapy remission group after treatment were lower than those in this group before treatment;all the differences were statistically significant(P<0.05).The differences in VEGF and LDH levels before and after treatment in the non-remission group were not statistically significant(P>0.05).β_(2)-MG levels before and after treatment in the chemotherapy remission group and the non-remission group were higher than those in the control group,andβ_(2)-MG(2.51±0.48)mg/L level after treatment in the chemotherapy remission group was lower than(3.85±0.85)mg/L before treatment in this group and(3.28±0.25)mg/L after treatment in the non-remission group;all the differences were statistically significant(P<0.05).There was no statistically significant difference in β_(2)-MG levels between the chemotherapy remission group and the non-remission group before treatment,and before and after treatment of the non-remission group(P>0.05).Conclusion The levels of VEGF,LDH andβ_(2)-MG are closely related to the diagnosis and prognosis of acute leukemia,and can reflect the tumor

关 键 词：血管内皮生长因子 乳酸脱氢酶 β_(2)-微球蛋白 急性白血病 

分 类 号：R733.71[医药卫生—肿瘤]