不同MYCN基因扩增状态腹部神经母细胞瘤CT表现  

CT manifestations of abdominal neuroblastoma with different MYCN gene amplification status

作　　者：王浩入 陈欣[1] 何玲[1] WANG Haoru;CHEN Xin;HE Ling(Department of Radiology,Children's Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院放射科国家儿童健康与疾病临床医学研究中心儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室,重庆400014

出　　处：《中国医学影像技术》2021年第11期1685-1688,共4页Chinese Journal of Medical Imaging Technology

基　　金：重庆市教育委员会科学技术研究项目(KJQN202000440);重庆市科卫联合医学科研项目(2020FYYX128);重庆市渝中区基础研究与前沿探索项目(20200155)。

摘　　要：目的观察不同MYCN基因扩增状态的腹部神经母细胞瘤(NB)CT表现。方法纳入172例腹部NB患儿,根据MYCN基因拷贝数分为MYCN组(n=47)及未扩增组(n=125)。比较组间肿瘤分布部位、大小、形态、密度、边界、钙化、囊变及坏死等CT征象差异;比较组间肿瘤实质的平均CT值及其与同一层面背部肌肉平均CT值差值的差异。结果组间肿瘤大小、分布部位、形态、钙化、囊变及坏死、跨越中线生长情况差异均有统计学意义(P均<0.05),而静脉期强化方式差异无统计学意义(P>0.05);组间肿瘤与血管关系及邻近脏器侵犯情况差异均有统计学意义(P均<0.05);未扩增组静脉期肿瘤实质平均CT值及与同一层面背部肌肉平均CT值差值均显著高于MYCN组(P均<0.05)。结论MYCN基因不同扩增状态的腹部NB肿瘤CT表现存在一定差异。Objective To observe CT manifestations of abdominal neuroblastoma(NB)with different MYCN gene amplification status.Methods A total of 172 pediatric patients with abdominal NB were enrolled and divided into MYCN group(n=47)and non-amplification group(n=125)according to the MYCN gene copy number.CT findings,such as lesion location,size,shape,density,margin,calcification,cystic degeneration and necrosis were compared between groups.The mean CT value of tumor parenchyma and the difference of mean CT value between tumor parenchyma and dorsal muscle on the same slice were both compared between groups.Results Statistical differences of lesion size,location,morphology,calcification,cystic degeneration,necrosis and infiltrating across midline were found between groups(all P<0.05),while there was no statistical difference of the way of tumor enhancement in venous phase(P>0.05).The relationship of tumor and blood vessels,and the invasion of adjacent organs were statistically different between groups(both P<0.05).The mean CT value of tumor parenchyma and the difference of mean CT value between tumor parenchyma and dorsal muscle on the same slice were both higher in non-amplification group than those in MYCN group(both P<0.05).Conclusion CT manifestations of abdominal NB with different MYCN gene amplification status were somehow different.

关 键 词：儿童 腹部 神经母细胞瘤 MYCN基因 体层摄影术 X线计算机 

分 类 号：R719[医药卫生—妇产科学] R814.42[医药卫生—临床医学]