十二指肠神经节细胞性副神经节瘤临床病理分析  

The clinicopathologic analysis of 76 cases of duodenal gangliocytic paraganglioma

作　　者：戢得天 刘晓波 周梦 吴婷 童强 JI De-tian;LIU Xiao-bo;ZHOU Meng;WU Ting;TONG Qiang(Postgraduate Training Base of Jinzhou Medical University in Shiyan Taihe Hospital,442000Shiyan,Hubei,China)

机构地区：[1]锦州医科大学太和医院研究生培养基地,湖北十堰442000

出　　处：《临床消化病杂志》2021年第5期326-329,共4页Chinese Journal of Clinical Gastroenterology

基　　金：太和医院重大精准医学研究项目(No:2016JD02);太和医院院级课题(No:2019JJXM032)。

摘　　要：[目的]回顾性分析76例十二指肠神经节细胞性副神经节瘤临床病理资料,提高临床医生对该病的认识。[方法]以"Gangliocytic paraganglioma of the duodenum"为检索词,检索Pubmed、Medline、Embase;以"十二指肠神经节细胞性副神经节瘤"为检索词,检索万方数据库、中国知网、维普数据库。时限自建库至2020年8月,系统回顾所有相关文献。[结果]检索到69篇文献,共76例患者,年龄3~92岁,主要症状腹痛、消化道出血、贫血,病变部位以十二指肠降部为主(56例,84.8%),多起源于黏膜下层(41例,64.1%),肿瘤直径5~80mm,11例(14.7%)患者出现器官或淋巴结转移,经手术切除并辅以术后放化疗,随访时间6周~8年未出现肿瘤复发或转移。[结论]十二指肠神经节细胞性副神经节瘤是一种罕见的肿瘤,预后良好。[Objective]The clinicopathologic data of duodenal gangliocytic paraganglioma were retrospectively analyzed to improve the clinical understanding of the rare disease.[Methods]With"Gangliocytic paraganglioma of the duodenum"as the search term,we systematically reviewed the relevant literatures on PubMed,Medline,Embase,Articles Database,China HowNet and VIP Database.[Results]A total of 76 patients were included in the study.The age of patients ranged from 3 to 92 years.The main clinical symptoms were included like stomachache,gastrointestinal bleeding and anemia.It mostly occurs in the second part of the duodenum(84.8%),mainly in the submucosa(64.1%).The tumor size ranged from 5 to 80 mm.The 14.6%of patients developed distant organ metastasis or lymph node metastasis and no tumor recurrence was found after surgical resection combined with postoperative chemoradiotherapy.[Conclusion]The duodenal gangliocytic paraganglioma is a rare cancer with favorable prognosis.

关 键 词：十二指肠神经节细胞性副神经节瘤 淋巴结转移 免疫组化 放化疗 

分 类 号：R730.264[医药卫生—肿瘤]