邻炔基苯基环丁酮类化合物的高效合成及其开环-环化反应  

Efficient Synthesis of o-Alkynylphenylcyclobutanone Compounds and Their Ring-Opening-Cyclization Reactions

作　　者：蔡润达 高继强 刘永盛 郭梓腾 王宇超 刘宇[1] CAI Runda;GAO Jiqiang;LIU Yongsheng;GUO Ziteng;WANG Yuchao;LIU Yu(College of Chemistry and Life Science,Changchun University of Technology,Changchun 130012,China)

机构地区：[1]长春工业大学化学与生命科学院,长春130012

出　　处：《吉林大学学报（理学版）》2021年第6期1577-1586,共10页Journal of Jilin University:Science Edition

基　　金：吉林省教育厅“十三五”科学技术研究项目(批准号:JJKH20181022KJ).

摘　　要：以常见易得且稳定的催化剂及膦配体为催化体系,进一步系统优化钯催化的无铜Sonogashira偶联制备β-(2-乙炔基苯基)环丁酮类化合物的反应体系,高产率得到一系列含有不同官能团的β-(2-乙炔基苯基)环丁酮类化合物,并进一步实现铜催化下该类化合物的开环-复分解反应.The commonly available and stable catalysts and phosphorus ligands were used as the catalytic system,we optimized the reaction system of palladium-catalyzed copper-free Sonogashira coupling to prepareβ-(2-phenylethynyl)cyclobutanone compounds.We obtained a series of alkynyl cyclobutanone compounds with different functional groups in high yields.Furthermore,the ring-opening-metathesis of these compounds catalyzed by copper was realized.

关 键 词：SONOGASHIRA反应 邻炔基苯基环丁酮 钯催化 LEWIS酸 环化反应 

分 类 号：O625.11[理学—有机化学]