肝损伤相关指标与急重症胰腺炎病情程度及NLR比值的关系  

Relationship between liver injury related indexes and severity of acute severe pancreatitis and NLR ratio

作　　者：董庆莲 李振平 DONG Qing-lian;LI Zhen-ping(Department of Critical Care Medicine,Dongying People's Hospital,Shandong 257091,China;Department of Pharmacy,Guangrao People's Hospital,Shandong 257300,China)

机构地区：[1]东营市人民医院重症医学科,山东257091 [2]广饶县人民医院药剂科

出　　处：《肝脏》2021年第9期1024-1026,共3页Chinese Hepatology

基　　金：山东省医药卫生科技发展计划(2017WS151)。

摘　　要：目的研究肝损伤相关指标与急重症胰腺炎病情程度及中性粒细胞与淋巴细胞比值(NLR)的关系。方法收集2018年10月至2020年10月在东营市人民医院接受治疗的90例急重症胰腺炎患者的临床资料,按照病情严重程度分成中度重症急性胰腺炎(MSAP)组和重症急性胰腺炎(SAP)组,每组45例,比较两组入院时外周血ALT、AST、碱性磷酸酶(ALP)、谷氨酰转肽酶(GGT)、总胆红素(TBil)、中性粒细胞计数、淋巴细胞计数、NLR水平,通过Spearman系数分析急重症胰腺炎病情严重程度与ALT、AST、TBil、中性粒细胞计数、NLR的相关性。结果SAP组ALT、AST、TBil水平高于MSAP组[(112.46±21.18)U/L比(84.77±14.56)U/L,(87.46±11.57)U/L比(67.16±9.16)U/L,(42.38±14.18)μmol/L比(34.58±17.89)μmol/L],差异均有统计学意义(t=7.227、9.228、7.629,均P<0.05)。SAP组中性粒细胞计数、NLR高于MSAP组[(9.27±1.07)×109/L比(8.41±1.34)×109/L,(8.41±2.48)比(6.18±1.04)],差异统计学意义(t=3.364、5.563,均P<0.05)。急重症胰腺炎病情严重程度与ALT、AST、TBil、中性粒细胞绝对值、NLR呈正相关(P<0.05)。结论肝损伤相关指标、NLR均可用于急重症胰腺炎病情程度的预测,且均与其存在明显相关性。Objective To study the relationship between liver injury related indexes and severity of acute severe pancreatitis and neutrophil lymphocyte ratio(NLR).Methods 90 patients with severe acute pancreatitis who were treated in our hospital from October 2018 to October 2020 were included in the study,and they were divided into moderate severe acute pancreatitis(MSAP)group and severe acute pancreatitis(SAP)group according to the severity of the disease,with 45 cases in each group.The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),glutamyl transpeptidase(GGT),total bilirubin(TBIL),absolute value of neutrophils,absolute value of lymphocytes and NLR were compared between the two groups.Spearman coefficient was used to analyze the correlation between the severity of severe acute pancreatitis and ALT,AST,TBIL,neutrophil absolute value,NLR.Results The levels of ALT,AST and TBIL in SAP group were significantly higher than those in MSAP group[(112.46±21.18)U/L vs(84.77±14.56)U/L,(87.46±11.57)U/L vs(67.16±9.16)U/L,(42.38±14.18)μmol/L vs(34.58±17.89)μmol/L].The difference was significant(P<0.05).The absolute value and NLR of neutrophils in SAP group were significantly higher than those in MSAP group[(9.27±1.07)×109/L vs(8.41±1.34)×109/L,(8.41±2.48)vs(6.18±1.04)].The difference was obvious(P<0.05).The severity of severe acute pancreatitis was positively correlated with ALT,AST,TBIL,neutrophil absolute value and NLR(P<0.05).Conclusion Liver injury related indicators and NLR can be used to predict the severity of severe acute pancreatitis,and there is a significant correlation between them.

关 键 词：急重症胰腺炎 中性粒细胞与淋巴细胞比值 肝损伤 

分 类 号：R575[医药卫生—消化系统] R576[医药卫生—内科学]