周剂量紫杉醇脂质体联合卡铂同步放化疗治疗局部晚期食管鳞状细胞癌的临床观察  

Weekly dose paclitaxel liposome combined carboplatin concurrent chemoradiotherapy for locally advanced esophageal cancer

作　　者：顾永娟 徐丽贤[1] 陈亚楠[1] 沈冬[1] 潘攀[1] GU Yongjuan;XU Lixian;CHEN Ya’nan;SHEN Dong;PAN Pan(Department of Oncology,Zhangjiagang First People’s Hospital,Zhangjiagang 215600,Jiangsu,China)

机构地区：[1]张家港市第一人民医院肿瘤科,江苏张家港215600

出　　处：《癌症进展》2021年第19期1995-1998,共4页Oncology Progress

摘　　要：目的观察周剂量紫杉醇脂质体联合卡铂同步放化疗治疗局部晚期食管鳞状细胞癌的疗效、预后及不良反应发生情况。方法将67例局部晚期食管鳞状细胞癌同步放化疗患者按化疗方案不同分为TC+RT组(33例)和FP+RT组(34例)。TC+RT组采用周剂量紫杉醇脂质体联合卡铂同步放化疗,FP+RT组采用氟尿嘧啶联合顺铂同步放化疗。比较两组患者的近期疗效及不良反应,随访观察生存情况。结果TC+RT组患者治疗有效率高于FP+RT组,差异有统计学意义(P﹤0.05)。TC+RT组患者白细胞减少发生率高于FP+RT组,胃肠道反应发生率低于FP+RT组,差异均有统计学意义(P﹤0.05)。TC+RT组和FP+RT组患者1、2、3年生存率比较,差异均无统计学意义(P﹥0.05)。结论周剂量紫杉醇脂质体联合卡铂同步放化疗治疗局部晚期食管鳞状细胞癌的近期疗效优于氟尿嘧啶联合顺铂,血液学不良反应TC+RT组高于FP+RT组,消化道反应则FP+RT组高于TC+RT组。两组患者远期生存率相仿,临床分期是非手术治疗食管癌患者预后的影响因素。Objective To observe the efficacy,prognosis and adverse reactions of weekly dose paclitaxel liposome combined carboplatin chemoradiotherapy in the treatment of locally advanced esophageal cancer.Method A total of 67 patients with locally advanced esophageal cancer and treated with concurrent chemoradiotherapy were divided into the TC+RT group(n=33,treated with weekly dose paclitaxel liposome+carboplatin concurrent chemoradiotherapy)and FP+RT group(n=34,treated with fluorouracil+cisplatin concurrent chemoradiotherapy);the short-term efficacy,adverse reactions and survival of the two groups were compared.Result The effective rate in TC+RT group was higher than that in the FP+RT(P<0.05);leukopenia rate in TC+RT group was higher than that in the FP+RT group(P<0.05);the incidence of gastrointestinal reactions in the FP+RT group was higher than that in the TC+RT group(P<0.05);there was no significant difference for the 1-year,2-year and 3-year survival rate between the two groups(P>0.05).Conclusion The efficacy of TC+RT group is superior to that of FP+RT group;the hematological toxicity of TC+RT group is higher than that of FP+RT group,and the gastrointestinal reaction of FP+RT group is higher than that of TC+RT group.The long-term survival rate is similar between the two groups,and the clinical stage is the main factor affecting the prognosis of patients with non-operative esophageal cancer.

关 键 词：晚期食管癌 同步放化疗 紫杉醇脂质体 卡铂 

分 类 号：R735.1[医药卫生—肿瘤]