乳腺区段切除术对绝经后乳腺癌患者的治疗效果及安全性分析  

Efficacy and safety of segmental mastectomy for postmenopausal breast cancer patients

作　　者：王炜鹏[1] 张涛[1] WANG Weipeng;ZHANG Tao(Department of General Surgery,Zhengzhou Second Hospital,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州市第二人民医院普外科,郑州450000

出　　处：《癌症进展》2021年第19期2002-2004,2035,共4页Oncology Progress

摘　　要：目的探讨乳腺区段切除术对绝经后乳腺癌患者的治疗效果及安全性。方法将98例乳腺癌患者根据手术方法的不同分为对照组和观察组,每组49例。对照组行改良根治术,观察组行乳腺区段切除术。比较两组患者的围手术期情况、并发症发生率、血清肿瘤标志物[癌胚抗原(CEA)、糖类抗原153(CA153)],随访1年评估患者临床疗效(生存率、局部复发率和远处转移发生率)、生活质量。结果观察组患者手术时间、住院时间均明显短于对照组,术中出血量明显少于对照组,切口长度明显小于对照组,差异均有统计学意义(P﹤0.01)。观察组患者并发症总发生率低于对照组(P﹤0.05)。两组患者的1年生存率、局部复发率和远处转移率比较,差异均无统计学意义(P﹥0.05)。术后1年,两组乳腺癌患者生命质量测量表(FACT-B)中生理、功能评分和对照组患者的情感、乳腺癌特异因素评分均低于本组治疗前(P﹤0.05),且观察组患者中情感、功能及乳腺癌特异因素评分均高于对照组(P﹤0.05)。结论乳腺区段切除术治疗绝经后乳腺癌患者的疗效良好,有利于改善患者围手术期状况、生活质量,降低术后并发症的发生风险。Objective To explore the efficacy and safety of segmental mastectomy for postmenopausal breast cancer patients.Method A total of 98 patients with breast cancer were divided into control group and observation group according to different surgical methods,49 cases in each group.The control group received modified radical mastectomy,and the observation group received segmental mastectomy.The perioperative situation,incidence of complications,serum tumor markers[carcinoembryonic antigen(CEA)and carbohydrate antigen 153(CA153)]were compared between the two groups.The clinical efficacy(survival rate,local recurrence rate and incidence of distant metastasis)and quality of life were evaluated during 1-year follow-up.Result The operation time and hospital stay time in the observation group were significantly shorter than those in the control group,the amount of intraoperative blood loss was significantly less than that in the control group,and the incision length was significantly shorter than that in the control group(P<0.01).The incidence of total complications in observation group was lower than that of control group(P<0.05).There were no significant differences in 1-year survival rate,local recurrence rate and distant metastasis rate between the two groups(P>0.05).After treatment 1 year,the scores of physiology and function in the functional assessment of cancer therapy-breast(FACTB)in the two groups and the scores of emotion and breast cancer specific factors in the control group were lower than those before treatment(P<0.05);the scores of emotion,function and breast cancer specific factors in the observation group were higher than those in the control group(P<0.05).Conclusion Segmental mastectomy is effective in the treatment of postmenopausal breast cancer,which can improve the perioperative status,quality of life and reduce the risk of postoperative complications.

关 键 词：乳腺癌 绝经期 乳腺区段切除术 改良根治术 

分 类 号：R737.9[医药卫生—肿瘤]