乳果糖与两种益生菌制剂三联用药治疗老年慢性功能性便秘的临床观察  

Clinical observation of the triple combination of lactulose and two probiotic preparations in the treatment of chronic functional constipation in the elderly people

作　　者：钱敏 刘丰兵 李镇 袁金 吴介元 孟翠翠 丁莉 QIAN Min;LIU Fengbing;LI Zhen;YUAN Jin;WU Jieyuan;MEN Cuicui;DING Li(Department of General Practice of Changbai Community Health Service Center,Yangpu District,Shanghai 200093,China;Anorectal Department of Central Hospital of Yangpu District,Shanghai 200090,China)

机构地区：[1]上海市杨浦区长白社区卫生服务中心全科,上海200093 [2]上海市杨浦区中心医院肛肠科,上海200090

出　　处：《上海医药》2021年第22期35-37,44,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:评价联合使用乳果糖和两种益生菌制剂治疗老年人慢性功能性便秘的疗效。方法:选取2019年1月至2020年10月上海市杨浦区长白社区卫生服务中心门诊收治的60岁以上老年慢性功能性便秘患者238例,随机分为试验组和对照组,各119例。对照组每晚口服乳果糖15 mL;试验组在对照组基础上加服两种益生菌制剂,每日三餐后口服培菲康420 mg、米雅40 mg。两组均治疗4周。应用Bristol大便分类法评估大便性状,Wexner便秘症状评分表评价患者便秘程度,比较治疗前后患者排便周期、便秘Wexner评分以及大便形状,评价疗效。结果:两组治疗后排便周期、Wexner评分及大便性状均较治疗前明显改善(P<0.05),两组间差异无统计学意义(P>0.05)。试验组泻药用量情况优于对照组,差异有统计学意义(P<0.05)。试验组用药不良反应少于对照组(P<0.05)。结论:乳果糖联合使用两种益生菌制剂治疗慢性功能性便秘疗效确切,改善肠道功能疗效优于单独使用乳果糖。Objective:To evaluate the efficacy of lactulose and two probiotic preparations in the treatment of chronic functional constipation in the elderly people.Methods:Two hundred and thirty-eight elderly patients over 60 years old with chronic functional constipation in Changbai Community Health Service Center of Yangpu District,Shanghai were selected from January 2019 to October 2020,and randomly divided into an experimental group and a control group with 119 cases in each group.The control group was given lactulose 15mL every night;the experimental group took two probiotic preparations on the basis of the control group,and took 420 mg of peifeikang and 40 mg of miya after three meals a day.Both groups were treated for two weeks.Bristol stool classification was used to evaluate the stool characteristics,and Wexner constipation symptom score was used to evaluate the degree of constipation to compare the defecation cycle,Wexner score of constipation and stool shape before and after treatment.Results:After treatment,the defecation cycle,Wexner score and stool characteristics of the two groups were significantly improved compared with those before treatment(P<0.05),and the difference between the groups was not statistically significant(P>0.05).The dosage of laxatives in the experimental group was better than that in the control group,and the difference was statistically significant(P<0.05).The adverse drug reactions in the experimental group were less than those in the control group(P<0.05).Conclusion:Lactulose combined with two probiotic preparations is effective in the treatment of chronic functional constipation,and the effect of improving intestinal function is better than lactulose alone.

关 键 词：便秘 乳果糖 益生菌 

分 类 号：R574.62[医药卫生—消化系统]