蒿芩清胆汤联合阿莫西林治疗慢性胆囊炎对患者清除氧自由基能力及胃肠激素水平的影响  

Effect of Amoxicillin Combined with Haoqin Qingdan Decoction on Oxygen Free Radical Scavenging Ability and Gastrointestinal Hormone Level for Patients with Chronic Cholecystitis

作　　者：汪黎明 蒋文俊 张瑞 WANG Liming;JIANG Wenjun;ZHANG Rui(Sichuan Provincial Second Hospital of Traditional Chinese Medicine,Chengdu Sichuan 610031,China)

机构地区：[1]四川省第二中医医院,四川成都610031

出　　处：《四川中医》2021年第10期110-113,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察蒿芩清胆汤辅助阿莫西林治疗慢性胆囊炎对患者清除氧自由基能力及胃肠激素水平的影响。方法:选取我院2016年2月~2019年2月收治的慢性胆囊炎患者102例,分为两组。对照组给予阿莫西林治疗,观察组给予蒿芩清胆汤辅助阿莫西林治疗,统计两组总有效率、复发率,检测两组治疗前后氧化应激因子、胃肠激素及炎症因子的变化。结果:治疗后,观察组的总有效率为94.12%,高于对照组的78.43%,组间比较发现,有统计学意义(P<0.05)。治疗前氧化应激因子、胃肠激素进行组间比较发现,无统计学意义(P>0.05),治疗后进一步组间比较发现,观察组超氧化物歧化酶(SOD)、胃动素(MTL)高于对照组(P<0.05),丙二醇(MDA)、血管活性肠肽(VIP)低于对照组(P<0.05)。治疗前炎症因子进行组间比较发现,无统计学意义(P>0.05),治疗后进一步组间比较发现,观察组白细胞介素-8(IL-8)高于对照组(P<0.05),超敏C反应蛋白(hs-CRP)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)低于对照组(P<0.05)。治疗期间,观察组的复发率为3.92%,低于对照组的80.00%,组间比较发现,有统计学意义(P<0.05)。结论:蒿芩清胆汤辅助阿莫西林治疗慢性胆囊炎可减轻炎症反应,清除氧自由基,调节胃肠激素,降低复发率。Objective:To analyze the effect of Haoqin Qingdan Decoction combined with Amoxicillin on oxygen free radical scavenging ability and gastrointestinal hormone level for patients with chronic cholecystitis.Methods:102 patients with chronic cholecystitis admitted in our hospital from February 2016 to February 2019 were divided into two groups.The controlled group was treated with Amoxicillin,the observation group was treated with Haoqin Qingdan Decoction to assist Amoxicillin.The total effective rate and recurrence rate of the two groups were counted.The changes of oxidative stress factor,gastrointestinal hormone and inflammatory factor were detected before and after treatment.Results:After treatment,the total effective rate of the observation group was 94.12%,which was higher than that of the controlled group which was 78.43%.The comparison between the two groups was statistically significant(P<0.05).There was no statistical significance(P>0.05)(P>0.05).After treatment,superoxide dismutase(SOD),motilin(MTL)in the observation group were higher than those in the controlled group(P<0.05),propylene glycol(MDA),vasoactive intestinal peptide(VIP)were lower than those in the controlled group(P<0.05).There was no significant difference in inflammatory factors before treatment(P>0.05).After treatment,interleukin-8(IL-8)in the observation group was higher than that in the controlled group(P<0.05),and C reactive protein(hs-CRP),interleukin-1β(IL-1),tumor necrosis factor-α(TNF-α)were lower than those in the controlled group(P<0.05).During the treatment period,the recurrence rate in the observation group was 3.92%,which was lower than that in the controlled group(80.00%P<0.05).Conclusion:Using Haoqin Qingdan Decoction combined with Amoxicillin in the treatment of chronic cholecystitis can reduce inflammatory reaction,eliminate oxygen free radicals,regulate gastrointestinal hormones and reduce recurrence rate.

关 键 词：蒿芩清胆汤 阿莫西林 慢性胆囊炎 氧自由基 胃肠激素 炎症反应 

分 类 号：R575.61[医药卫生—消化系统]