颅内未破裂动脉瘤破裂风险因素研究进展  

Research progress of the risk of rupture of unruptured intracranial aneurysm

作　　者：丁煜昊 王剑刃[1] 谢涛 傅西安[1] Ding Yuhao;Wang Jianren;Xie Tao;Fu Xi'an(Department of Neurosurgery,Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou 215008,China)

机构地区：[1]南京医科大学附属苏州医院神经外科,215008

出　　处：《国际外科学杂志》2021年第10期700-705,共6页International Journal of Surgery

基　　金：苏州市临床重点病种诊疗技术专项基金(LCZX201913)。

摘　　要：颅内动脉瘤破裂是自发性蛛网膜下腔出血的主要病因,具有很高的致死、致残率。未破裂的颅内动脉瘤广泛存在于普通人群之中,筛选高危动脉瘤进行预防性干预有积极的作用。本文从颅内动脉瘤的流行病学、病理学、形态学及血流动力学等方面,对颅内动脉瘤破裂的风险因素进行综述。在流行病学方面,吸烟史、高血压、年龄、性别、家族遗传都与颅内动脉瘤破裂风险密切相关,在病理学方面,颅内动脉瘤壁上的炎症可能与动脉瘤破裂的风险有关。在影像学方面,颅内动脉瘤的大小、位置、动脉瘤壁的特征以及一些形态学及血流动力学参数可作为评价破裂风险因素的指标,同时颅内动脉瘤的生长情况也是高危指标之一,这些指标对于今后建立颅内未破裂动脉瘤的破裂风险因素评价模型具有重要意义。Intracranial aneurysms will lead to subarachnoid hemorrhage,which has a high mortality and morbidity risk.Screening high-risk aneurysms for preventive intervention has a positive effect,considering the widespread presence of unruptured aneurysms in the general population,this article reviews the risk factors of aneurysm rupture from the aspects of epidemiology,pathology,morphology and hemodynamics.In terms of epidemiology,smoking history,hypertension,age,gender and family inheritance are all closely related to the risk of aneurysm rupture.In terms of pathology,inflammation on the wall of intracranial aneurysm may be related to the risk of aneurysm rupture.In imaging,the size of intracranial aneurysms,location,the characteristics of the artery wall and some morphological and hemodynamic parameters can be used as evaluation index of fracture risk factors,cit the same time the growth of intracranial aneurysm is one of the high risk indicators,the indicators for us in the future to establish intracranial unruptured aneurysms rupture risk factors evaluation model is of great significance.

关 键 词：颅内动脉瘤 病理学 形态学 血液动力学 风险因素 

分 类 号：R743.35[医药卫生—神经病学与精神病学]