三维腔内后装放疗在原发性阴道癌中的临床应用观察  

Clinical application of 3-dimensional intracavitary retroperitoneal radiotherapy in primary vaginal carcinoma

作　　者：陈元平[1] 邓江华[1] 郭小青[1] 蔡璐[1] 何静[1] CHEN Yuanping;DENG Jianghua;GUO Xiaoqing;CAI Lu;HE Jing(Department of Oncology,Ganzhou People's Hospital,Ganzhou,Jiangxi,341000,China)

机构地区：[1]赣州市人民医院肿瘤科,江西赣州341000

出　　处：《当代医学》2021年第33期6-8,共3页Contemporary Medicine

基　　金：江西省赣州市科技计划立项课题(GZ2018ZSF303)。

摘　　要：目的观察原发性阴道癌患者实施三维腔内后装放疗治疗的临床价值。方法回顾性分析2015年6月至2018年8月本院收治的60例原发性阴道癌患者的临床资料,根据治疗方法不同分为A组和B组,每组30例。A组实施二维腔内后装放疗,B组实施三维腔内后装放疗。比较两组患者疾病控制率、2年局部复发率、2年生存率、治疗3个月内早期放疗不良反应(放射性阴道炎、放射性直肠炎)发生率及治疗3个月后晚期放疗不良反应(放射性直肠炎、直肠阴道瘘)的发生率。结果治疗后,两组疾病控制率比较差异无统计学意义。B组2年生存率为96.67%,明显高于A组(P<0.05);B组2年局部复发率为3.33%,治疗3个月内放射性阴道炎、放射性直肠炎发生率分别为10.00%和13.33%,治疗3个月后放射性直肠炎、直肠阴道瘘发生率分别为6.67%和3.33%,均明显低于A组(P<0.05)。结论与二维腔内后装放疗治疗比较,原发性阴道癌患者使用三维腔内后装放疗的临床价值更高,不仅能提高阴道癌患者的疗效,且能降低放疗带来的早期及晚期不良反应,提高患者的生活质量,值得临床推广应用。Objective To observe the primary vagina cancer patients after the implementation of 3-dimensional intracavitary retroloading radiotherapy with the clinical value of radiotherapy treatment.Methods The clinical data of 60 patients with primary vaginal cancer admitted to our hospital from June 2015 to August 2018 were retrospectively analyzed.According to different treatment methods,they were divided into group A and group B,with 30 cases in each group.Group A was treated with 2-dimensional intracavitary retroloading radiotherapy,and group B was treated with 3-dimensional intracavitary retroloading radiotherapy.The disease control rates,2 years local recurrence,2 years survival rate,incidence of early radiotherapy side effects within three months(radioactive vaginitis,radiation proctopathy),and incidence of late radiotherapy side effects(radiation proctitis,rectovaginal fistula)after 3 months of treatment were compared between two groups.Results After treatment,there was no statistically significant difference in disease control rate between the two groups.The 2 years survival rate was 96.67%of group B,significantly higher than group A(P<0.05);the 2 years local recurrence rate of group B was 3.33%,the incidence of early radiotherapy side effects(radiation vaginitis,radiation rectitis)within 3 months of treatment was 10.00%and 13.33%,respectively,the incidence of enterovaginal fistula was 6.67%and 3.33%,respectively,which were significantly lower than those of group A(P<0.05).Conclusion Compared with the treatment of 2-dimensional intracavitary retroloading radiotherapy,the clinical value of 3-dimensional intracavitary retroloading radiotherapy for primary vaginal cancer patients is more significant.It can not only improve the efficacy of cervical cancer patients,but also reduce the early and late side effects brought by radiotherapy,and improve the quality of life of patients,it is worthy of clinical application.

关 键 词：原发性阴道癌(COPD) 二维腔内后装放疗 三维腔内后装放疗 临床疗效 不良反应 

分 类 号：R737.34[医药卫生—肿瘤]