通过饮食和运动改变生活方式进行减肥治疗非酒精性脂肪性肝病(专家评述)——美国胃肠病协会临床实践更新  

AGA clinical practice update on lifestyle modification using diet and exercise to achieve weight loss in the management of nonalcoholic fatty liver disease:expert review

作　　者：李莉(译)[1] 展玉涛(审校)[1] LI Li;ZHAN Yutao(Department of Gastroenterology,Beijing Tongren Hospital Affiliated to Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院消化内科,北京100730

出　　处：《胃肠病学和肝病学杂志》2021年第11期1201-1206,共6页Chinese Journal of Gastroenterology and Hepatology

摘　　要：非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是慢性肝病的主要病因,累及超过全球人口的25%。NAFLD与肝硬化、肝细胞癌、实体器官恶性肿瘤、糖尿病、心血管疾病和阻塞性睡眠呼吸暂停的发病率和死亡率显著增加相关,导致了大量医疗资源使用,降低了健康相关生活质量。NAFLD相关性肝硬化已成为美国肝移植的主要病因。通过改变生活方式减肥仍然是NAFLD患者的一线干预措施。本文,我们总结了生活方式改变治疗NAFLD的循证干预措施并提出了处理其临床关键问题了最佳实践建议。Nonalcoholic fatty liver disease(NAFLD)is a leading cause of chronic liver disease,with global public health impact affecting more than 25%of the global population.NAFLD is associated with significant morbidity and mortality from cirrhosis,hepatocellular carcinoma,solid organ malignancies,diabetes mellitus,cardiovascular disease,and obstructive sleep apnea,resulting in significant health care resource use and decreased health-related quality of life.NAFLD cirrhosis is a leading indication for liver trans plantation in the United States.Lifestyle modification to achieve weight loss remains a first-line intervention in patients with NAFLD.We summarized evidence-based interventions for lifestyle modification in the treatment of NAFLD and provided best practice advice statements to address key issues in clinical management.

关 键 词：脂肪肝 脂肪性肝炎 非酒精性脂肪性肝炎 减肥 运动 饮食 肝纤维化 肥胖 肝硬化 

分 类 号：R575[医药卫生—消化系统]