血清IL-33表达水平与原发性肝癌患者预后的相关性研究  

Correlation between serum IL-33 expression level and prognosis of patients with primary liver cancer

作　　者：吴虹杰[1] 游焜[2] 卓亚 WU Hongjie;YOU Kun;ZHUO Ya(Department of Infectious Diseases,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China;Department of Hepatobiliary Surgery,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院感染科,河南新乡453100 [2]新乡医学院第一附属医院肝胆外科,河南新乡453100

出　　处：《胃肠病学和肝病学杂志》2021年第11期1245-1250,共6页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨原发性肝癌(primary liver cancer,PLC)患者术前血清白细胞介素-33(interleukin-33,IL-33)水平与预后的关系。方法纳入2015年1月至2017年12月于我院就诊的365例PLC患者(PLC组)和30名健康体检者(对照组)作为研究对象,采用ELISA法检测并比较两组研究对象血清中IL-33表达水平的差异。对365例PLC患者进行术后随访24个月,分析术后6个月内复发、6个月~1年内复发及术后1~2年内复发的患者术前血清IL-33表达水平的差异,PLC患者术后复发的影响因素通过Logistic回归分析,PLC患者术前血清IL-33表达水平预测术后复发的临床效能采用受试者操作特征(receiver operating characteristic,ROC)曲线分析,采用Kaplan-Meier生存分析评估PLC患者术前血清IL-33表达水平与术后复发的相关性。结果PLC组和对照组血清IL-33表达水平分别为(254.87±20.36)ng/ml和(90.25±17.08)ng/ml,与对照组相比,PLC组血清IL-33表达水平显著升高,差异有统计学意义(t=43.044,P<0.000)。随访24个月后,PLC患者术后复发共129例,复发率为35.34%,其中术后6个月内复发43例,术后6个月~1年内复发59例,术后1~2年内复发27例,术后三组复发患者血清IL-33表达水平依次为(304.16±30.23)ng/ml、(278.19±29.31)ng/ml和(251.07±19.38)ng/ml,三组间比较,差异有统计学意义(F=26.335,P<0.001),与术后6个月~1年内复发患者比较,术后6个月内复发患者血清IL-33表达水平显著升高(q=4.361,P<0.000),而术后1~2年内复发患者血清IL-33表达水平显著降低(q=4.382,P<0.000)。单因素分析结果显示,PLC患者术后复发与肿瘤细胞分化程度、肿瘤大小、肿瘤数目、门静脉癌栓和术前血清IL-33表达水平有关(P<0.05)。Logistic回归分析结果显示,门静脉癌栓(OR=8.478)、术前血清IL-33水平(OR=5.223)和肿瘤细胞分化程度(OR=2.235)均是PLC患者术后复发的独立危险因素。PLC患者术前血清IL-33表达水平诊断术后复发的曲线下面积为0.941(95%CI:0.916Objective To investigate the relationship between serum interleukin-33(IL-33)expression level and prognosis of patients with primary liver cancer(PLC).Methods A total of 365 patients with PLC(PLC group)and 30 healthy controls(control group)were enrolled in our hospital from Jan.2015 to Dec.2017.The serum IL-33 expression level in PLC patients before operation was detected and compared between two groups by ELISA methods.The 365 PLC patients after postoperative with 24 months of follow-up and the cases of recurrence within 6 months,6 months to 1 year and 1 to 2 years were recorded.The serum IL-33 expression level before operation among 3 groups were compared.The influencing factors of recurrence in PLC patients were analyzed by Logistic regression analysis.The serum IL-33 expression level in PLC patients before operation to predict the clinical efficacy of postoperative recurrence via receiver operating characteristic(ROC)curve.The Kaplan-Meier survival analysis was used to evaluate the correlation between preoperative serum IL-33 expression level of PLC patients and postoperative recurrence.Results The serum IL-33 expression levels in the PLC group and the control group were(254.87±20.36)ng/ml and(90.25±17.08)ng/ml,respectively.Compared with the control group,the expression level of serum IL-33 in the PLC group was significantly higher,with statistically significant difference(t=43.044,P<0.000).With 24 months of follow-up,a total of 129 PLC patients recurred and the recurrence rate was 35.34%.Among 129 PLC patients,43 cases,59 cases and 27 cases recurred within 6 months after operation,6 months to 1 year after operation and 1 to 2 years after operation,respectively.The serum IL-33 expression level before operation in 3 groups was(304.16±30.23)ng/ml,(278.19±29.31)ng/ml and(251.07±19.38)ng/ml,respectively.The differences among 3 groups were statistically significant(F=26.335,P<0.001).Compared with patients recurred within 6 months to 1 year after operation,the serum IL-33 expression level in patients recurred

关 键 词：原发性肝癌 白细胞介素-33 复发 影响因素 生存分析 

分 类 号：R735.7[医药卫生—肿瘤]