血清表皮生长因子及受体、胰岛素样生长因子和结合蛋白在结直肠癌患者中的表达及其与疾病分期的关系  

Expression of Serum Epidermal Growth Factor and Its Receptor,Insulin-like Growth Factor and Binding Protein in Patients with Colorectal Cancer and Their Relationship with Disease Stage

作　　者：朱红珍 沈建东[1] 俞志忠 ZHU Hongzhen;SHEN Jiandong;YU Zhizhong(Changshu Second People’s Hospital,Changshu 215500,China;不详)

机构地区：[1]江苏省常熟市第二人民医院,江苏常熟215500

出　　处：《中国医学创新》2021年第31期147-150,共4页Medical Innovation of China

摘　　要：目的:探究血清表皮生长因子及受体、胰岛素样生长因子及结合蛋白在结直肠癌患者中的表达及其与疾病分期的关系。方法:选取2018年10月-2021年2月的80例结直肠癌患者为观察组,同时期的80例结直肠良性病变患者为对照组。检测与比较两组的血清表皮生长因子(EGF)、表皮生长因子受体(EGFR)、胰岛素样生长因子1(IGF-1)、胰岛素样生长因子结合蛋白2(IGFBP-2)、胰岛素样生长因子结合蛋白3(IGFBP-3),并比较观察组中不同部位及疾病分期患者上述指标的水平,采用Spearman秩相关分析上述血清指标与结直肠癌疾病分期的关系。结果:观察组的血清EGF、EGFR、IGF-1、IGFBP-2均显著高于对照组,血清IGFBP-3显著低于对照组,观察组中不同疾病分期患者的上述指标的水平比较,差异均有统计学意义(P<0.05);观察组中不同部位患者的上述指标水平比较,差异均无统计学意义(P>0.05)。Spearman秩相关分析显示,血清EGF、EGFR、IGF-1、IGFBP-2与结直肠癌的疾病分期均呈正相关,血清IGFBP-3与结直肠癌的疾病分期呈负相关(P<0.05)。结论:结直肠癌患者血清表皮生长因子及受体、胰岛素样生长因子及结合蛋白均呈异常表达的状态,且与结直肠癌的疾病分期密切相关,因此在结直肠癌患者中的检测价值较高。Objective:To investigate the expression of serum epidermal growth factor and receptor,insulinlike growth factor and binding protein in patients with colorectal cancer and its relationship with disease stage.Method:A total of 80 patients with colorectal cancer from October 2018 to February 2021 were chosen as the observation group,80 patients with benign colorectal lesions at the same time were chosen as the control group.Serum epidermal growth factor(EGF),epidermal growth factor receptor(EGFR),insulin-like growth factor 1(IGF-1),insulin-like growth factor binding protein 2(IGFBP-2),insulin-like growth factor binding protein 3(IGFBP-3)were detected and compared between the two groups,Spearman rank correlation was used to analyze the relationship between the above serum indexes and colorectal cancer stage.Result:Serum EGF,EGFR,IGF-1 and IGFBP-2 in the observation group were significantly higher than those in the control group,while serum IGFBP-3 was significantly lower than that in the control group.there were statistically significant differences in the levels of above indicators in patients with different disease stages in the observation group(P<0.05);there were no statistical significance in the levels of above indexes in different parts of the observation group(P>0.05).Spearman rank correlation analysis showed that serum EGF,EGFR,IGF-1 and IGFBP-2 were positively correlated with the stage of colorectal cancer,while serum IGFBP-3 was negatively correlated with the stage of colorectal cancer(P<0.05).Conclusion:The expression of serum epidermal growth factor and its receptor,insulin-like growth factor and its binding protein of patients with colorectal cancer are abnormal,and they all have close relationship with the disease stages of colorectal cancer,so the detection value in the patients with colorectal cancer are higher.

关 键 词：结直肠癌 表皮生长因子 表皮生长因子受体 胰岛素样生长因子 胰岛素样生长因子结合蛋白 

分 类 号：R735.34[医药卫生—肿瘤]