帕利哌酮联合心理疏导在紧张型精神分裂症木僵状态患者中的应用效果及对肝功能的影响研究  

Study on the Effect of Paliperidone Combined with Psychological Counseling in Patients with Catatonic Schizophrenia with Stupor State and Its Influence on Liver Function

作　　者：王庆蕾 WANG Qinglei(Corning Hospital of Chaoyang City,Chaoyang 122000,China)

机构地区：[1]辽宁省朝阳市康宁医院,辽宁朝阳122000

出　　处：《中国医学创新》2021年第31期176-180,共5页Medical Innovation of China

摘　　要：目的:探讨帕利哌酮联合心理疏导在紧张型精神分裂症木僵状态患者的应用效果及对肝功能的影响。方法:选取2017年2月-2018年1月在本院就诊的98例紧张型精神分裂症木僵状态患者,根据治疗方法不同将其分为观察组(n=50)和对照组(n=48)。对照组采用奥氮平药物进行治疗,观察组在对照组的基础上给予帕利哌酮联合心理疏导治疗。比较两组治疗前后阳性和阴性症状评定量表(PANSS)评分、肝功能[谷草转氨酶(AST)、谷丙转氨酶(ALT)、谷氨酰转肽酶(GGT)]、生活质量评分,比较两组不良反应发生情况。结果:治疗前,两组PANSS总分、阳性症状、阴性症状评分比较,差异均无统计学意义(P>0.05);治疗后,两组PANSS总分、阳性症状、阴性症状评分均低于治疗前,且观察组圴低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组ALT、AST、GGT比较,差异均无统计学意义(P>0.05);治疗后,两组AST、ALT、GGT均高于治疗前,但观察组圴低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组心理健康、生活质量、社会关系、精神状态评分比较,差异均无统计学意义(P>0.05);治疗后,两组心理健康、生活质量、社会关系、精神状态评分均高于治疗前,且观察组均高于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为8.00%低于对照组的22.92%,差异有统计学意义(P<0.05)。结论:帕利哌酮联合心理疏导治疗紧张型精神分裂症木僵状态患者效果明显,可有效降低PANSS评分,提高患者生活质量且对肝功能影响小,安全性高,值得临床推广使用。Objective:To explore the effect of Paliperidone combined with psychological counseling in patients with catatonic schizophrenia with stupor state and its influence on liver function.Method:A total of 98 patients with catatonic schizophrenia with stupor state treated in our hospital from February 2017 to January 2018 were selected,and they were divided into observation group(n=50)and control group(n=48)according to different treatment methods.The control group was treated with Olanzapine,and the observation group was treated with Paliperidone combined with psychological counseling on the basis of the control group.The positive and negative symptom rating scale(PANSS)score,liver function[aspartate aminotransferase(AST),alanine aminotransferase(ALT),glutamyl transpeptidase(GGT)]and quality of life score before and after treatment were compared between two groups,and the occurrence of adverse reactions was compared between two groups.Result:Before treatment,there were no significant differences in PANSS total scores,positive symptom scores and negative symptom scores between two groups(P>0.05);after treatment,PANSS scores,positive symptoms scores and negative symptoms scores in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in ALT,AST and GGT between two groups(P>0.05);after treatment,AST,ALT and GGT in both groups were higher than those before treatment,but those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in mental health,quality of life,social relationship and mental state scores between the two groups(P>0.05);after treatment,the scores of mental health,quality of life,social relationship and mental state in 2 groups were higher than before,and the observation group were higher than those in th

关 键 词：紧张型精神分裂症 木僵状态 帕利哌酮 心理疏导 生活质量 肝功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]