自体血回输对骨科手术患者抗氧化能力与红细胞损伤的影响研究  

Effect of Autologous Blood Transfusion on Antioxidant Capacity and Erythrocyte Injury in Orthopedic Surgery Patients

作　　者：喻斌[1] YU Bin(Pingxiang People’s Hospital,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市人民医院,江西萍乡337000

出　　处：《中国医学创新》2021年第29期74-77,共4页Medical Innovation of China

基　　金：江西省卫健委(中医药管理局)科技计划项目(SKJP220201059)。

摘　　要：目的:研究与观察自体血回输对骨科手术患者抗氧化能力与红细胞损伤情况的影响。方法:选取2019年1月-2020年12月本院80例骨科手术患者,根据输血方式的不同将其分为对照组和观察组,每组40例。对照组采用异体血输血,研究组采用自体血回输。比较两组不良反应发生情况,术前和术后1、7 d的抗氧化能力指标(血清SOD、MDA、TAC、CAT),术前及术后12、24 h的红细胞损伤指标(NO、ATP)和血乳酸指标(aLac及vLac)。结果:术前,两组SOD、MDA、TAC、CAT比较,差异均无统计学意义(P>0.05);术后1、7 d,观察组SOD、MDA、TAC、CAT均优于对照组,差异均有统计学意义(P<0.05)。术前,两组总NO、ATP比较,差异均无统计学意义(P>0.05);术后12、24 h,观察组总NO、ATP均高于对照组,差异均有统计学意义(P<0.05)。术前,两组aLac、vLac比较,差异均无统计学意义(P>0.05);术后12、24 h,观察组aLac、vLac均低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:自体血回输可提高骨科手术患者的抗氧化能力,降低红细胞损伤,降低输血相关不良反应发生率,因此在骨科手术患者中的应用价值较高。Objective:To study and observe the effect of autologous blood transfusion on antioxidant capacity and erythrocyte injury in patients undergoing orthopedic surgery.Method:A total of 80 patients underwent orthopedic surgery in our hospital from January 2019 to December 2020 were selected,and they were divided into control group and observation group according to different transfusion methods,40 cases in each group.Allogeneic blood transfusion was used in the control group and autologous blood transfusion was used in the study group.The incidence of adverse reactions,antioxidant capacity indexes(serum SOD,MDA,TAC,CAT),erythrocyte injury(NO,ATP)and blood lactic acid indexes(aLac and vLac)were compared between two groups.Result:Before surgery,there were no significant differences in SOD,MDA,TAC and CAT between two groups(P>0.05);1,7 d after surgery,SOD,MDA,TAC and CAT in the observation group were better than those in the control group,the differences were statistically significant(P<0.05).Before surgery,there were no significant differences in total NO and ATP between two groups(P>0.05);at 12,24 h after surgery,total NO and ATP in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Before surgery,there were no significant differences in aLac and vLac between two groups(P>0.05);at 12 and 24 h after surgery,aLac and vLac in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Autologous blood transfusion can improve the antioxidant capacity,reduce erythrocyte injury and reduce the incidence of transfusion related adverse reactions in patients with orthopedic surgery,therefore,it has high application value in patients with orthopedic surgery.

关 键 词：自体血回输 骨科手术 抗氧化能力 红细胞损伤 

分 类 号：R457.1[医药卫生—治疗学] R687.3[医药卫生—临床医学]