基于“无虚不作痫”理论治疗痫病的临床疗效评价  

Evaluation of the Clinical Efficacy of the Treatment of Epilepsy Based on the Theory of“No-deficiency,No Epilepsy”

作　　者：洪荣庆 黎胜驹 李玉红 李莲英 关锦贞 陈瑶 HONG Rongqing;LI Shengju;LI Yuhong;LI Lianying;GUAN Jinzhen;CHEN Yao(Yangjiang Hospital of Traditional Chinese Medicine,Yangjiang 529500,China;不详)

机构地区：[1]广东省阳江市中医医院,广东阳江529500

出　　处：《中国医学创新》2021年第29期91-94,共4页Medical Innovation of China

基　　金：2020年度广东中医药局科研立项项目(20202250)。

摘　　要：目的:探究基于"无虚不作痫"的理论,采用清心汤辨证加减联合丙戊酸钠缓释片应用于痫病的临床效果。方法:选取2019年1月1日-2020年9月1日阳江市中医医院80例癫痫患者,采用随机数字表法将其分为对照组与治疗组,每组40例。对照组采用丙戊酸钠缓释片治疗,治疗组采用清心汤辨证加减联合丙戊酸钠缓释片治疗。比较两组不良反应发生情况,治疗8、16周和治疗后8、16周的疗效,治疗前后症候积分、癫痫症状周发作频次及持续时间。结果:治疗8、16周及治疗后8、16周,治疗组总有效率均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组症候积分比较,差异无统计学意义(P>0.05);治疗后,两组症候积分均低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组癫痫周发作频次、发作持续时间比较,差异均无统计学意义(P>0.05);治疗后,两组癫痫周发作频次及发作持续时间均少于治疗前,且治疗组均少于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:基于"无虚不作痫"的理论,采用清心汤辨证加减联合丙戊酸钠缓释片治疗痫病效果显著,可改善患者临床症状,安全性高,值得应用与推广。Objective:To explore the clinical effect of Qingxin Decoction syndrome differentiation modified and Sodium Valproate Sustained-release Tablets in epilepsy based on the theory of"no-deficiency,no epilepsy".Method:A total of 80 patients with epilepsy in Yangjiang Hospital of Traditional Chinese Medicine from January 1,2019 to September 1,2020 were selected,and they were divided into control group and treatment group according to random number table method,40 patients in each group.The control group was treated with Sodium Valproate Sustained-release Tablets,and the treatment group was treated with Qingxin Decoction syndrome differentiation modified combined with Sodium Valproate Sustained-release Tablets.The incidence of adverse reactions and the efficacy of 8,16 weeks of treatment and 8,16 weeks after treatment,syndrome scores before and after treatment,weekly frequency and duration of epilepsy were compared between two groups.Result:8,16 weeks of treatment and 8,16 weeks after treatment,the total effective rate of the treatment group were higher than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in syndrome scores between two groups(P>0.05);after treatment,the syndrome scores of both groups were lower than those before treatment,and that of the treatment group was lower than that of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the weekly frequency and duration of epilepsy between two groups(P>0.05);after treatment,the weekly frequency and duration of epilepsy of both groups were less than those before treatment,those of the treatment group were less than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion:Based on the theory of“no-deficiency,no epilepsy”,the Qingxin Decoction syndrome differentiati

关 键 词：癫痫 无虚不作痫 清心汤 丙戊酸钠缓释片 

分 类 号：R742.1[医药卫生—神经病学与精神病学]