立体定向放疗治疗早期非小细胞肺癌的效果及对E-selectin和炎症因子的影响  

Effects of Stereotactic Radiotherapy in the Treatment of Early Non-small Cell Lung Cancer and Its Effects on E-selectin and Inflammatory Cytokines

作　　者：王清睿[1] WANG Qingrui(The Sixth Hospital of Wuhan,Wuhan 430015,China)

机构地区：[1]武汉市第六医院,湖北武汉430015

出　　处：《中国医学创新》2021年第30期43-46,共4页Medical Innovation of China

摘　　要：目的:探讨立体定向放疗(stereotactic body radiation therapy,SBRT)治疗早期非小细胞肺癌(non-small cell lung cancer,NSCLC)的效果及对患者血清中E-selectin和炎症因子的影响。方法:选取2016年5月-2018年11月于本院行根治性肺叶切除术或SBRT治疗的80例早期NSCLC患者,根据治疗方法的不同将其分成两组,每组40例。于术前及术后7 d测定外周血中E-selectin和IL-6、IL-8、CRP、PGE2等炎症因子含量,比较两组手术前后E-selectin、炎症因子水平及生存情况。结果:术后7 d,两组IL-6、IL-8、CRP、PGE2水平均较术前升高,且手术组上述指标均高于SBRT组,差异均有统计学意义(P<0.05)。术后7 d,两组E-selectin水平均较术前降低,差异均有统计学意义(P<0.05)。术后7 d,两组E-selectin水平比较,差异无统计学意义(P>0.05)。SBRT组的1、3、5年生存率分别为92.5%、86.7%、72.7%,与手术组的90.0%、85.3%、70.8%比较,差异均无统计学意义(P>0.05)。SBRT组并发症发生率低于手术组,差异有统计学意义(P<0.05)。结论:与胸腔镜肺癌根治术相比,SBRT对机体的创伤较小,并发症少,可以明显降低机体的急性炎症反应,且不影响患者的远期疗效。Objective:To study on stereotactic body radiation therapy (SBRT) in the treatment of early non-small cell lung cancer (NSCLC) and its effect on serum E-selectin and inflammatory cytokines in patients.Method:A total of 80 patients with early NSCLC who underwent radical lobotomy or SBRT treatment in our hospital from May 2016 to November 2018 were selected,according to different treatment methods,they were divided into two groups,40 cases in each group.The levels of E-selectin and inflammatory factors such as IL-6,IL-8,CRP and PGE;in peripheral blood were determined before and 7 d after surgery,the levels of E-selectin and inflammatory factors and survival situation were compared between the two groups before and after surgery.Result:7 d after surgery,the levels of IL-6,IL-8,CRP and PGE;in both groups were increased compared with those before surgery,and the above indexes in surgery group were higher than those in SBRT group,the differences were statistically significant (P<0.05).7 d after surgery,the level of E-selectin in both groups were lower than those before surgery,the differences were statistically significant (P<0.05).There was no significant difference in the level of E-selectin between two groups at 7 d after surgery (P>0.05).The 1-year,3-year and 5-year survival rates of SBRT group were 92.5%,86.7% and 72.7%,respectively,compared with 90.0%,85.3% and 70.8% of surgery group,and there were no statistical significance (P>0.05).The incidence of complications in the SBRT group was lower than that in the surgery group,the difference was statistically significant (P<0.05).Conclusion:Compared with thoracoscopic radical resection of lung cancer,SBRT has less trauma and fewer complications,can significantly reduce the acute inflammatory response of the body,and does not affect the long-term efficacy of patients.

关 键 词：早期非小细胞肺癌 胸腔镜 SBRT 炎症因子 

分 类 号：R734.2[医药卫生—肿瘤]