经尿道膀胱肿瘤等离子整块剜除术与经尿道膀胱肿瘤电切术在非肌层浸润性膀胱癌中的应用效果  

Application of transurethral plasma enucleation of bladder tumor and transurethral resection of bladder tumor in non-muscular invasive bladder cancer

作　　者：张守鹏[1] ZHANG Shou-peng(Department of Urology,Dandong Central Hospital,Liaoning Province,Dandong118000,China)

机构地区：[1]辽宁省丹东市中心医院泌尿外科,辽宁丹东118000

出　　处：《中国当代医药》2021年第32期95-98,共4页China Modern Medicine

摘　　要：目的分析比较经尿道膀胱肿瘤等离子整块剜除术(TeURBT)与经尿道膀胱肿瘤电切术(TURBT)治疗非肌层浸润性膀胱癌的临床疗效及1年随访情况。方法回顾性分析2018年6月至2019年12月丹东市中心医院泌尿外科接收的92例非肌层浸润性膀胱癌患者作为研究对象,根据手术方法的不同将其分为A组和B组,每组各46例。其中A组行TURBT术,B组行TeURBT术,分析比较两组患者的围手术期指标、并发症发生情况、血清指标及复发情况。结果B组的手术操作时间长于A组,而尿管留置、膀胱冲洗及住院时间均短于A组,同时术中失血量少于A组,差异有统计学意义(P<0.05)。B组术后并发症总发生率低于A组,差异有统计学意义(P<0.05)。两组术后3个月时复查时的单核细胞趋化蛋白-1(MCP-1)、人类软骨糖蛋白-39(YKL40)及血管内皮生长因子(VEGF)表达低于本组术前,差异有统计学意义(P<0.05);但两组间MCP-1、YKL40、VEGF比较,差异无统计学意义(P>0.05)。B组术后1年时的累计复发率为6.52%,低于A组的21.74%,差异有统计学意义(P<0.05)。结论TeURBT与TURBT治疗非肌层浸润性膀胱癌均可取得显著效果,但TeURBT在改善围手术期指标,降低并发症以及复发率方面的效果更具优势。Objective To compare and analyze the clinical efficacy and 1-year follow-up of transurethral plasma enucleation of bladder tumor(TeURBT)and transurethral resection of bladder tumor(TURBT)in the treatment of non-muscular invasive bladder cancer.Methods A retrospective analysis of 92 patients with non-muscular invasive bladder cancer admitted to the Department of Urology in the Dandong Central Hospital from June 2018 to December 2019 was conducted.They were divided into the group A and the group B according to different surgical methods,with 46 patients in each group.The group A were given TURBT operation and the group B were given TeURBT operation.The perioperative indicators,complications,serum indicators and recurrence were compared and analyzed between the two groups.Results The operation time in the group B was longer than that in the group A,while the duration of catheter indwelling,bladder irrigation and hospitalization in the group B were shorter than those in the group A,and the blood loss during operation in the group B was less than that in the group A,with statistically significant differences(P<0.05).The total incidences of postoperative complications in the group B was lower than that in the group A,with statistically significant difference(P<0.05).The expressions of monocyte chemoattractant protein-1(MCP-1),human cartilage glycoprotein-39(YKL40)and vascular endothelial growth factor(VEGF)at the time of reexamination were lower than those before surgery,with statistically significant differences(P<0.05).But there were no statistically significant differences of MCP-1,YKL40 and VEGF between the two groups(P>0.05).The cumulative recurrence rate at 1 year after operation in the group B was 6.52%,which was lower than that in the group A as 21.74%,with statistically significant difference(P<0.05).Conclusion Both TeURBT and TURBT can achieve significant effects in the treatment of non-muscular invasive bladder cancer,but TeURBT has more advantages in improving perioperative indicators,and reducing incidence

关 键 词：经尿道膀胱肿瘤等离子整块剜除术 经尿道膀胱肿瘤电切术 非肌层浸润性膀胱癌 临床疗效 复发 

分 类 号：R737.14[医药卫生—肿瘤]