青钱柳叶的化学成分研究  

Chemical Constituents from Leaves of Cyclocarya paliurus

作　　者：李龙宇 罗荣华 徐明杰 伍一炜 赵迪 潘巧玲 金佳怡 赵田甜 徐暾海[1] 郑晓杰[4] 姜程曦 朱寅荻 LI Long-yu;LUO Rong-hua;XU Ming-jie;WU Yi-wei;ZHAO Di;PAN Qiao-ling;JIN Jia-yi;ZHAO Tian-tian;XU Tun-hai;ZHENG Xiao-jie;JIANG Cheng-xi;ZHU Yin-di(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China;Institute of Life Sciences,Wenzhou University,Wenzhou 325035,China;School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou 325035,China;Wenzhou Vocational College of Science and Technology,Wenzhou 325000,China)

机构地区：[1]北京中医药大学中药学院,北京102488 [2]温州大学生命科学研究院,浙江温州325035 [3]温州医科大学药学院,浙江温州325035 [4]温州科技职业学院,浙江温州325000

出　　处：《中国现代中药》2021年第10期1705-1709,共5页Modern Chinese Medicine

基　　金：浙江省科技计划项目(2017C02039);文成县创新创业种子资金项目(2018NKY02)。

摘　　要：目的:研究青钱柳叶的化学成分。方法:将青钱柳叶乙醇提取物用正丁醇、石油醚、乙酸乙酯分别萃取3次;采用D101型大孔吸附树脂、硅胶、ODS、SephadexLH-20和制备高效液相色谱等柱色谱方法对青钱柳叶的正丁醇萃取部位进行分离纯化,利用核磁共振(NMR)对分离得到的化合物进行结构鉴定。结果:从青钱柳叶中分离得到10个化合物,分别是山柰酚(1)、杜仲树脂酚(2)、(+)-松脂醇(3)、(+)-表松脂醇(4)、积雪草酸(5)、山楂酸(6)、熊果酸(7)、1α,3β-二羟基-12-齐墩果烯-28-酸(8)、石榴萜酮(9)、青钱柳苷Ⅰ(10)。结论:化合物2~4、8均为首次从青钱柳属植物中分离得到。Objective:To study the chemical constituents from leaves of Cyclocarya paliurus.Methods:The ethanol extract of C.paliurus leaves was extracted with petroleum ether,ethyl acetate,and n-butanol three times,respectively.The n-butanol fractions were separated and purified by D101 macroporous resin,silica gel column chromatography,octadecylsilyl(ODS)semi-preparative chromatography,Sephadex LH-20,and high performance liquid chromatography(HPLC),and the structures of the yielded compounds were identified by nuclear magnetic resonance(NMR).Results:Ten compounds were isolated from C.paliurus leaves:kaempferol(1),medioresinol(2),(+)-pinoresinol(3),(+)-epipinoresinol(4),asiatic acid(5),maslinic acid(6),ursolic acid(7),1α,3β-dihydroxy-12-oleanen-28-oic acid(8),punicaone(9),cyclocariosideⅠ(10).Conclusion:Compounds 2-4 and 8 were isolated from Cyclocarya for the first time.

关 键 词：青钱柳 三萜 木脂素 化学成分 结构鉴定 

分 类 号：R284[医药卫生—中药学]