不同干燥方法对苦地丁药材品质的影响  

Effects of Different Drying Methods on Quality of Corydalis Bungeanae Herba

作　　者：王圆圆 李超 谷巍[1] 巢建国[1] 毛春芳[3] 王凯 惠西珂 WANG Yuan-yuan;LI Chao;GU Wei;CHAO Jian-guo;MAO Chun-fang;WANG Kai;HUI Xi-ke(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210000,China;Jumpcan Pharmaceutical Group Co.,Ltd.,Taixing 225400,China;Nantong Health College of Jiangsu Province,Nantong 226000,China)

机构地区：[1]南京中医药大学药学院,江苏南京210000 [2]济川药业集团有限公司,江苏泰兴225400 [3]江苏省南通卫生高等职业技术学校,江苏南通226000

出　　处：《中国现代中药》2021年第10期1762-1769,共8页Modern Chinese Medicine

基　　金：中医药公共卫生服务补助专项(财社〔2019〕39号);2020年江苏省科研与实践创新计划项目(SJCX20-0530)。

摘　　要：目的:比较不同干燥方法对苦地丁药材品质的影响,优选出苦地丁的干燥工艺。方法:采集河北安国的地丁草鲜品,分别采用传统和现代工艺干燥方法处理,采用高效液相色谱-三重四极杆飞行时间质谱法对不同干燥方法处理的苦地丁药材70%乙醇提取物化学成分及相对含量进行综合分析,优选出适宜的干燥方法。结果:对不同干燥方法的苦地丁药材定性分析,共鉴定出37个差异化学成分,以37个差异化学成分为指标进行主成分分析,结合药材外观形状、干燥时间及能耗综合分析,结果显示鼓风50℃、晒干法均为适宜的干燥方法。结论:不同的干燥方法对苦地丁品质影响较大,通过多元指标分析可以为苦地丁的适宜干燥方法的筛选提供参考。Objective:To compare the effects of different drying methods on the quality of Corydalis Bungeanae Herba and select the optimal drying process.Methods:Fresh Corydalis bungeana Turcz.was collected from Anguo,Hebei and dried with conventional and modern methods,separately.HPLC-Triple-TOF-MS/MS was used to comprehensively analyze the chemical constituents of the 70%ethanol extract of Corydalis Bungeanae Herba and the relative content and thereby the optimal drying methods were determined.Results:Qualitative analysis identified 37 differential chemical constituents.Based on the principal component analysis of the 37 constituents,and the appearance,drying time,and energy consumption of the medicinal materials,blasting at 50℃and drying in the sun were considered as the optimal drying methods.Conclusion:The quality of Corydalis Bungeanae Herba processed with different drying methods varied greatly.The multi-index analysis can provide scientific basis for screening of suitable drying methods for Corydalis Bungeanae Herba.

关 键 词：苦地丁 高效液相色谱-三重四极杆飞行时间质谱法 干燥方法 药材品质 

分 类 号：R282.4[医药卫生—中药学]