前列腺健康指数及f/tPSA对于PSA“灰区”前列腺癌诊断价值比较的Meta分析  

Prostate health index versus free/total PSA for prostate cancer detection in patients with PSA levels in“gray area”:a systematic analysis

作　　者：贾伟 吴波 陈骞 张旭辉[1] 王东文 Jia Wei;Wu Bo;Chen Qian;Zhang Xuhui;Wang Dongwen(Department of Urology,the First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Urology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518116,China)

机构地区：[1]山西医科大学第一医院,太原030001 [2]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院泌尿外科,深圳518116

出　　处：《中华腔镜泌尿外科杂志（电子版）》2021年第6期478-483,共6页Chinese Journal of Endourology(Electronic Edition)

基　　金：山西省重点研发计划(社会发展领域)(201803D31110);山西医科大学第一医院创新团队基金(YT1604);山西省“1331工程”重点创新团队建设计划资助(1331KIRT)。

摘　　要：目的系统评价前列腺健康指数(PHI)及游离/总前列腺特异性抗原(f/tPSA)对于PSA=“灰区”(2~10 ng/ml)前列腺癌诊断价值的比较。方法通过检索Pubmed、Cochrane图书馆、Embase、中国学术期刊全文数据库、维普期刊全文数据库5个数据库,收集报告PHI、f/tPSA在PSA“灰区”前列腺癌诊断价值的文献。使用MetaDisc 1.4软件、STATA 11.0进行统计分析。结果共12篇文献,4639例研究对象纳入Meta分析。穿刺诊断前列腺癌患者1703例,穿刺阴性2936人。PHI、f/tPSA合并敏感性分别为0.87(95%CI:0.85~0.89)、0.86(95%CI:0.84~0.87);合并特异性分别为0.42(95%CI:0.40~0.44),0.24(95%CI:0.22~0.25);ROC曲线下面积PHI:0.803,f/tPSA=0.644(P<0.001)。结论PHI较%fPSA在PSA“灰区”前列腺癌诊断中存在明显优势。Objective To investigate the value of prostate health index and free/total PSA(f/tPSA)of prostate cancer detection in patients with PSA levels between 2-10 ng/ml“gray area”.Methods Relevant articles in 5 online databases Pubmed,Embase,Cochrane library,CNKI,VIP were enrolled.Systematic analysis was performed by MetaDisc 1.4,STATA 11.0.Results 12 articles and 4639 patients were included in present analysis.As a result,a total of 1703 patients was confirmed prostate cancer,number of patients with negative prostate biopsies was 2936.The pooled sensitivity of PHI and f/tPSA were 0.87(95%CI:0.85-0.89)vs 0.86(95%CI:0.84-0.87),respectively,the pooled specificity of PHI and%fPSA were 0.42(95%CI:0.40-0.44)vs 0.24(95%CI:0.22-0.25).The ROC of PHI and f/tPSA were 0.803 vs 0.644(P<0.001).Conclusion PHI has a obvious advantage over the f/tPSA for prostate cancer detection in patients with PSA levels of“gray area”.

关 键 词：前列腺健康指数 前列腺特异性抗原 前列腺癌 META分析 

分 类 号：R737.25[医药卫生—肿瘤]