Bcl-2和C-myc在胆管癌中的表达及意义的研究  

Expression and Significance of Bcl-2 and C-myc in Cholangiocarcinoma

作　　者：张大坤[1] ZHANG Dakun(The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China)

机构地区：[1]蚌埠医学院第一附属医院,安徽蚌埠233000

出　　处：《中外医学研究》2021年第28期73-75,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：蚌埠医学院科技发展基金项目(BYKF1863)。

摘　　要：目的:观察胆管癌患者中Bcl-2和C-myc表达情况,以分析Bcl-2和C-myc和胆管癌病理关系及在疾病发生、进展中的作用。方法:本次研究对象为笔者医院普外科2018年4月-2020年4月收治的40例胆管癌患者。将40例患者的癌旁组织标本作为对照组,将40例患者的胆管癌组织标本作为试验组。两组均通过免疫组化方法测定Bcl-2和C-myc表达情况,观察两组不同标本中Bcl-2和C-myc表达情况,同时分析胆管癌中Bcl-2、C-myc表达和癌症分化程度、癌组织学级别及胆管癌转移的关系。结果:试验组C-myc、Bcl-2阳性表达率高于对照组,差异有统计学意义(P<0.05)。高分化腺癌和黏液腺癌的C-myc阳性表达率均高于低分化腺癌,差异有统计学意义(P<0.05),而高分化腺癌、低分化腺癌、黏液腺癌之间Bcl-2阳性表达率比较差异无统计学意义(P>0.05)。Ⅰ级胆管癌组织C-myc阳性表达率高于Ⅱ、Ⅲ级,差异有统计学意义(P<0.05),而Ⅰ、Ⅱ、Ⅲ级之间Bcl-2阳性表达率比较差异无统计学意义(P>0.05)。转移的患者C-myc阳性表达率明显高于无转移的患者,差异有统计学意义(P<0.05),而转移的患者和无转移的患者Bcl-2阳性表达率比较差异无统计学意义(P>0.05)。结论:Bcl-2和C-myc在胆管癌组织中存在明显异常表达,其中C-myc体现了胆管癌的恶性程度,在反映胆管癌发病机制中意义重大。Objective:To observe the expression of Bcl-2 and C-myc in patients with cholangiocarcinoma,and to analyze the pathological relationship between Bcl-2 and C-myc and the roles in the occurrence and progression of cholangiocarcinoma.Method:The subjects of this study were 40 patients with cholangiocarcinoma admitted in the department of general surgery of our Hospital from April 2018 to April 2020.Paracancerous tissue samples from 40 patients were taken as the control group,and cholangiocarcinoma tissue samples from 40 patients were taken as the experimental group.The expression levels of Bcl-2 and C-myc in two groups were detected by immunohistochemical method.The expression of Bcl-2 and C-myc in different specimens of two groups were observed.The relationship between the expression of Bcl-2 and C-myc in cholangiocarcinoma and the degree of differentiation,histological grade and metastasis of cholangiocarcinoma was analyzed.Result:The positive expression rate of C-myc and Bcl-2 in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).The positive expression rates of C-myc in well differentiated adenocarcinoma and mucinous adenocarcinoma was higher than that in poorly differentiated adenocarcinoma,and the difference was statistically significant(P<0.05),while there was no significant difference in the positive expression rate of Bcl-2 among well differentiated adenocarcinoma,poorly differentiated adenocarcinoma and mucinous adenocarcinoma(P>0.05).The positive expression rate of C-myc in grade Ⅰ cholangiocarcinoma was higher than that in grade Ⅱ and Ⅲ,and the difference was statistically significant(P<0.05),while there was no significant difference in the positive expression rate of Bcl-2 among grade Ⅰ,Ⅱ and Ⅲ(P>0.05).The positive expression rate of C-myc in patients with metastasis was significantly higher than that in patients without metastasis,the difference was statistically significant(P<0.05),while there was no significant diffe

关 键 词：胆管癌 BCL-2 C-MYC 分化程度 转移 

分 类 号：R735.8[医药卫生—肿瘤]