IL-23/IL-17通路及调节网络在葡萄膜炎发生中的作用  

Role of IL-23/IL-17 pathway and regulatory network in the pathogenesis of uveitis

作　　者：易圣蓝(综述) 杨培增(审校)[1] Yi Shenglan;Yang Peizeng(Department of Ophthalmology,The First Affiliated Hospital of Chongqing Medical University,Chongqing Key Laboratory of Ophthalmology,Chongqing Eye Institute,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院眼科,眼科学重庆市市级重点实验室,重庆市眼科研究所,400016

出　　处：《中华实验眼科杂志》2021年第11期1010-1016,共7页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金青年项目(82000884)。

摘　　要：葡萄膜炎是一类发病机制尚不完全清楚的致盲率较高的眼病。近年来,研究发现白细胞介素(IL)-23/IL-17通路在葡萄膜炎发生中起着重要作用。IL-23/IL-17信号通路以辅助性T细胞17活化为主线,作用于靶细胞,造成炎性因子、趋化因子的大量产生及视网膜色素上皮屏障功能的破坏,进而引起葡萄膜炎的发生。IL-23/IL-17通路受庞大的网络调节,多个正向及负向调节因子通过调节该通路引起免疫失调,从而参与葡萄膜炎的发生。IL-23/IL-17通路及调节网络中基因的多态性与葡萄膜炎密切相关,为研究葡萄膜炎的遗传发病机制提供了重要的基础。此外,临床试验已证实靶向IL-23/IL-17通路生物制剂的疗效,为葡萄膜炎的治疗提供了新的研究方向。本文对IL-23/IL-17通路及其生理功能进行概述,对葡萄膜炎中IL-23/IL-17通路及其调节网络正向、负向调节因子和基因多态性进行总结分析,并对葡萄膜炎中IL-23/IL-17通路生物制剂研究进展进行综述,以期加深对葡萄膜炎发病机制的认识,从而指导临床治疗。Uveitis is an inflammatory disease,a leading cause of blindness,the pathogenesis of which is not fully understood.In recent years,it has been found that interleukin(IL)-23/IL-17 pathway plays an important role in the occurrence of uveitis.The IL-23/IL-17 pathway mainly acts on target cells through activating the T helper 17 cells,resulting in the production of inflammatory factors and chemokines as well as the damage of retinal pigment epithelium,which can cause uveitis.The IL-23/IL-17 pathway is regulated by a giant network,and the regulation of it by its positive and negative factors can lead to immune disorders and participate in the occurrence of uveitis.The polymorphism of genes in IL-23/IL-17 pathway and regulatory network is closely related to uveitis,which provides an important basis for the genetic pathogenesis of uveitis.In addition,clinical trials have confirmed the efficacy of biological agents targeting IL-23/IL-17 pathway,which provides a new research direction for the treatment of uveitis.The IL-23/IL-17 pathway and its physiological function,the positive and negative factors and gene polymorphism of IL-23/IL-17 pathway and its regulatory network in uveitis were summarized,and the research progress of biological agents of IL-23/IL-17 pathway in uveitis were reviewed in this article in order to deepen the understanding of the pathogenesis of uveitis and guide clinical practice.

关 键 词：辅助性T细胞17 信号通路 葡萄膜炎 IL-23/IL-17通路 调节网络 

分 类 号：R773.9[医药卫生—眼科]