注射用丹参多酚酸治疗缺血性脑卒中对患者同型半胱氨酸、D-二聚体、高敏C反应蛋白水平与血液流变指标影响  

Effects of Salvianolic Acids for Injection on the Levels of Homocysteine,D-Dimer,Hypersensitive C-reactive Protein and Hemorheology in Patients with Ischemic Stroke

作　　者：李剑萍 LI Jianping(Hospital of Traditional Chinese Medicine,Taishan 529200,China)

机构地区：[1]台山市中医院,广东台山529200

出　　处：《中外医学研究》2021年第29期25-28,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究注射用丹参多酚酸(SAFI)治疗缺血性脑卒中对患者同型半胱氨酸(Hcy)、D-二聚体(D-Dimer)、高敏C反应蛋白(hs-CRP)水平与血液流变指标影响。方法:选择2018年3月-2021年3月于本院接受治疗的106例缺血性脑卒中患者为观察对象,将2018年3月-2019年8月收治的患者纳入参考组(n=52),予以常规药物治疗(包括阿司匹林肠溶片、华法林);将2019年9月-2021年3月收治的患者纳入观察组(n=54),在参考组基础上予以SAFI治疗。对比两组治疗前、治疗2周后的Hcy、D-Dimer、hs-CRP水平;对比两组治疗前、治疗2周后的血液流变指标[包括血小板聚集率、全血高切黏度、血浆黏度(PV)];对比两组治疗期间的不良反应发生率。结果:治疗2周后,观察组Hcy、D-Dimer、hs-CRP水平均低于参考组,差异有统计学意义(P<0.05)。治疗2周后,观察组血小板聚集率、全血高切黏度、PV水平均低于参考组,差异有统计学意义(P<0.05)。两组治疗期间的不良反应发生率比较,差异无统计学意义(P>0.05)。结论:SAFI治疗缺血性脑卒中可有效改善患者的病情及其血液流变指标,安全性良好。Objective:To investigate the effects of Salvianolic Acids for Injection(SAFI)on the levels of homocysteine(Hcy),D-Dimer(D-Dimer),hypersensitivity C-reactive protein(hs-CRP)and hemorheological indexes in patients with ischemic stroke.Method:A total of 106 patients with ischemic stroke who received treatment in our hospital from March 2018 to March 2021 were selected as the observation objects.Patients admitted from March 2018 to August 2019 were included in the reference group(n=52)and received conventional drug therapy(including Aspirin Enteric-cured Tablets and Warfarin);patients admitted from September 2019 and March 2021 were included in the observation group(n=54)and treated with SAFI on the basis of the reference group.The levels of Hcy,D-Dimer and hs-CRP in the two groups before treatment and 2 weeks after treatment were compared.The hemorheological indexes[including platelet aggregation rate,whole blood high shear viscosity,plasma viscosity(PV)]were compared between the two groups before treatment and 2 weeks after treatment.The incidence of adverse reactions during treatment was compared between the two groups.Result:After 2 weeks of treatment,the levels of Hcy,D-Dimer and hs-CRP in the observation group were lower than those in the reference group,the differences were statistically significant(P<0.05).After 2 weeks of treatment,the platelet aggregation rate,whole blood high shear viscosity and PV in the observation group were lower than those in the reference group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:SAFI treatment of ischemic stroke can effectively improve the patients’condition and its blood rheology,and also improve the hemorheological indexes,with good safety.

关 键 词：注射用丹参多酚酸 缺血性脑卒中 同型半胱氨酸 D-二聚体 高敏C反应蛋白 血液流变指标 

分 类 号：R743.3[医药卫生—神经病学与精神病学]