不确定潜能的克隆性造血与心血管疾病的相关研究进展  

The Correlation Between Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Diseases

作　　者：李彤[1] 郭宏[1,2] LI Tong;GUO Hong(Harbin Medical University Graduate School,Harbin 150000,Heilongjiang,China;Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin 150000,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学研究生院,黑龙江哈尔滨150000 [2]哈尔滨医科大学附属第一医院心内科,黑龙江哈尔滨150000

出　　处：《心血管病学进展》2021年第11期961-964,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金面上项目(81874281)。

摘　　要：传统的危险因素已不能完全预测心血管疾病(CVD)的发展,最新研究表明,造血系统的体细胞突变与CVD之间存在以前未被认识到的联系。炎症反应是CVD的主要发病机制之一,而动物模型显示,不确定潜能的克隆性造血(CHIP)的相关突变放大了炎症反应,同时CHIP患者炎症标志物水平升高,增加了CVD风险。随着第二代测序技术被广泛应用于临床,CHIP患者的管理已成为一个迅速兴起的热点,因此深入探讨CHIP致CVD的机制有重要临床意义,也为今后寻找有效防治措施提供了理论基础。Traditional risk factors can’t completely predict the development of cardiovascular diseases(CVD).New research shows that there is a previously unrecognized connection between somatic mutation in hematopoietic system and CVD.Inflammatory reaction is one of the main pathogenesis of CVD.Animal models show that the mutations related to clonal hematopoiesis of indeterminate potential(CHIP)amplify the inflammatory reaction,and the level of inflammatory markers in CHIP patients increases,which increases the risk of CVD.With the second generation sequencing techniques being widely used in clinic,the management of CHIP patients has become a hot spot.Therefore,in-depth exploration of the mechanism of CHIP-induced CVD has important clinical significance and provides a theoretical basis for finding effective prevention and treatment measures in the future.

关 键 词：不确定潜能的克隆性造血 心血管疾病 基因突变 

分 类 号：R54[医药卫生—心血管疾病]