Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery  

作　　者：M.Kurdtabar S.Saif Heris M.Dezfulian 

机构地区：[1]Department of Chemistry,Karaj Branch,Islamic Azad University,Karaj 31485-313,Iran [2]Department of Microbiology,Karaj Branch,Islamic Azad University,Karaj 31485-313,Iran

出　　处：《Chinese Journal of Polymer Science》2021年第12期1597-1608,共12页高分子科学（英文版）

摘　　要：Nanocomposite hydrogels are one of the most important types of biomaterials which can be used in many different applications such as drug delivery and tissue engineering.Incorporatio n of nano particles within a hydrogel matrix can provide unique characteristics like remote stimulate and improved mechanical strength.In this study,the synthesis of graphene oxide and graphene oxide nanocomposite hydrogel has been studied.Nanocomposite hydrogel was synthesized using carboxymethyl cellulose as a natural base,acrylic acid as a comonomer,graphene oxide as a filler,ammonium persulfate as an initiator,and iron nanoparticles as a crosslinking agent.The effect of reaction variables such as the iron nanoparticles,graphene oxide,ammonium persulfate,and acrylic acid were examined to achieve a hydrogel with maximum absorbency.Doxorubicin,an anti-cancer chemotherapy drug,was loaded into this hydrogel and its release behaviors were examined in the phosphate buffer solutions with different pH values.The structure of the graphene oxide and the optimized hydrogel were confirmed by Fourier-transform infrared spectroscopy,Raman spectroscopy,X-ray diffraction,scanning electron microscopy,and atomic force microscopy.

关 键 词：Nanocomposite hydrogel Carboxymethyl cellulose Graphene oxide DOXORUBICIN Drug delivery 

分 类 号：TQ460.4[化学工程—制药化工] TQ427.26