吐温表面活性剂囊泡对姜黄素的包载作用  

Entrapment Effect of Tween Surfactant Niosomes on Curcumin

作　　者：郝兴坤 郑雨晴 王倩 张玉珂 许贺翔 夏新宇 王小永[1] Hao Xingkun;Zheng Yuqing;Wang Qian;Zhang Yuke;Xu Hexiang;Xia Xinyu;Wang Xiaoyong(School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai,200237)

机构地区：[1]华东理工大学化学与分子工程学院,上海200237

出　　处：《化学通报》2021年第11期1243-1247,共5页Chemistry

基　　金：国家自然科学基金项目(21573071)资助。

摘　　要：本文研究了烷基链不饱和度对吐温表面活性剂囊泡包载姜黄素的影响。相比吐温-80囊泡,吐温-60囊泡的包载使姜黄素表现出更大的紫外吸收和荧光发射强度、缔合常数和DPPH自由基清除能力。^(1)H NMR结果表明姜黄素缔合于吐温-60囊泡双分子层中的亲水头基附近,而且姜黄素的酚羟基与吐温-60的酯基产生氢键作用。在吐温-80囊泡中,双键会使吐温-80烷基链产生弯曲或折叠,导致双分子层排列更加松散、极性更高。因此,姜黄素除了与吐温-80的酯基产生氢键作用外,还能与吐温-80烷基链尾部和中部的亚甲基发生作用。The effect of alkyl chain unsaturation on the properties of entrapped curcumin by Tween surfactant niosomes was investigated.Compared with Tween-80 niosomes,the entrapment of Tween-60 niosomes enables curcumin to exhibit higher UV absorption and fluorescence emission intensities,binding constant,and DPPH free radical scavenging ability.^(1)H NMR results revealed that curcumin is bound close to the hydrophilic headgroup in the bilayer of Tween-60 niosomes,and the phenolic hydroxyl group of curcumin forms the hydrogen bond with the ester group of Tween-60.However,in the bilayer of Tween-80 niosomes with looser arrangement and higher polarity caused by the double bond,curcumin not only has hydrogen bond interaction with the ester group of Tween-80,but also can interact with the methylene groups in the middle and terminal of the alkyl chain of Tween-80.

关 键 词：非离子表面活性剂 囊泡 姜黄素 双键 缔合常数 

分 类 号：TQ423.2[化学工程] TQ460.4