大环内酯类药物非抗菌作用及其在支气管扩张症治疗中的应用研究进展  

Non-antibacterial effects of macrolides and the application in the treatment of bronchiectasis

作　　者：王昊(综述)[1] 徐保平(审校)[1] Wang Hao;Xu Baoping(Department of Respiratory Disease I,Beijing Children′s Hospital,Capital Medical University,National Clinical Research Center for Respiratory Diseases,National Center for Children′s Health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,国家呼吸系统疾病临床研究中心,首都医科大学附属北京儿童医院呼吸一科,100045

出　　处：《国际儿科学杂志》2021年第10期657-660,共4页International Journal of Pediatrics

基　　金：北京市医院管理中心儿科学科协同发展中心专项经费(XTZD20180104)。

摘　　要：大环内酯类药物具有抑制炎症反应、减少气道黏液分泌、降低病原体载量等非抗菌作用。儿童支气管扩张症严重影响患儿生存质量和生长发育,目前尚无特效治疗,感染、慢性气道炎症、黏液纤毛清除作用受损参与其发生发展,大环内酯类药物的非抗菌作用可在这些环节发挥作用。该文就大环内酯类药物的非抗菌作用在儿童囊性纤维化、非囊性纤维化支气管扩张症、原发性纤毛运动障碍治疗中的有效性、安全性等应用研究的进展进行综述,供临床实践参考。Macrolide antibiotics have corresponding non-antibacterial effects in inhibiting inflammatory response,reducing airway mucus secretion,and reducing pathogen load.Bronchiectasis seriously affects the quality of life and growth of children.Currently,there is no specific treatment for bronchiectasis.Infection,chronic airway inflammation,and impaired mucociliary clearance are involved in the development of bronchiectasis.The non-antibacterial effects of macrolides in the treatment of cystic fibrosis,non-cystic fibrosis related bronchiectasis,and primary ciliary dyskinesia are reviewed in order to provide reference for pediatricians in clinical practice.

关 键 词：支气管扩张症 囊性纤维化 大环内酯类药物 

分 类 号：R56[医药卫生—呼吸系统]