环状RNA与视网膜发育和视网膜疾病的相关性  

Relationship between circular RNA and retinal development and retinal diseases

作　　者：姜美霞 林婷婷 Jiang Meixia;Lin Tingting(Tianjin International Joint Research Center of Ophthalmology and Visual Science,Tianjin Key Laboratory of Retinal Function and Disease,Ophthalmic Hospital,College of Ophthalmology and Optometry,Institute of Ophthalmology,Tianjin Medical University,Tianjin 300384,China)

机构地区：[1]天津医科大学眼科医院、眼视光学院、眼科研究所天津市视网膜功能与疾病重点实验室天津市眼科学与视觉科学国际联合研究中心,300384

出　　处：《国际眼科纵览》2021年第5期455-458,共4页International Review of Ophthalmology

基　　金：天津市临床重点学科团队建设项目(TJLCZDXKT006);天津市临床重点学科青年建设项目(TJLCZDXKQ024)。

摘　　要：环状RNA(circRNA)是真核生物中普遍存在的一类特殊的非编码RNA分子,呈闭合环状结构,具有高度的保守性和稳定性,在多种疾病中具有调节作用。circRNA可参与调控视网膜炎症、细胞凋亡、血管生成以及氧化应激反应等,在眼部发育及疾病进展中发挥着重要调控作用。CircRNA的改变可能早于眼底改变,因此在组织、唾液、血液和外泌体中检测到的circRNA有望作为视网膜疾病(如青光眼、糖尿病视网膜病变、增生性玻璃体视网膜病变、年龄相关性黄斑变性等)的诊断及预后判定的生物标志物。对circRNA表达的干预可显著影响血管内皮细胞的生物学功能,调控血管通透性,有望作为一种基因治疗手段为视网膜疾病的治疗提供新方向。Circular RNA(circRNA)is a special type of non-coding RNA molecule ubiquitous in eukaryotes.It has a closed loop structure,and is highly conservative and stable,and has a regulatory role in a variety of diseases.CircRNA can participate in the regulation of retinal inflammation,cell apoptosis,angiogenesis,and oxidative stress response,etc.,and plays an important regulatory role in eye development and disease progression.The change of circRNA may be earlier than the change of the fundus morphology,so the circRNA detected in tissues,saliva,blood and exosomes is expected to be used for biomarkers for diagnosis and prognosis of retinal diseases(such as glaucoma,diabetic retinopathy,proliferative vitreoretinopathy,age-related macular degeneration,etc.).Intervention of circRNA expression can significantly affect the biological functions of vascular endothelial cells and regulate vascular permeability.It is expected to be used as a gene therapy method to provide a new direction for the treatment of retinal diseases.

关 键 词：环状RNA 视网膜疾病 

分 类 号：R774.1[医药卫生—眼科]