健康体检人群不同分型幽门螺杆菌感染与代谢综合征的关系  

Relationship between different types of helicobacter pylori infection and metabolic syndrome in healthy people

作　　者：刘浚沅 贺永梅 侯晓琳 崔梅花 Liu Junyuan;He Yongmei;Hou Xiaolin;Cui Meihua(Department of Gastroenterology,Aerospace Center Hospital&Peking University Aerospace School of Clinical Medicine,Beijing 100049,China;Department of Health Management,Aerospace Center Hospital&Peking University Aerospace School of Clinical Medicine,Beijing 100049,China)

机构地区：[1]航天中心医院,北京大学航天临床医学院消化科,100049 [2]航天中心医院,北京大学航天临床医学院健康管理部,100049

出　　处：《中国综合临床》2021年第6期555-559,共5页Clinical Medicine of China

摘　　要：目的探讨健康体检人群中不同分型幽门螺杆菌(helicobacter pylori,Hp)感染与代谢综合征(metabolic syndrome,MS)之间的关系。方法收集2019年1-12月在航天中心医院进行健康体检的成年人4602名数据进行研究,采用免疫印迹法进行血清Hp抗体分型的检测,收集肝脏超声检查结果及血液生化检查等资料进行统计分析。结果体检人群中血清Hp抗体阳性者为2018例,血清Hp抗体阴性者为2584例。通过血清Hp抗体分型检测,根据是否表达细胞毒素相关蛋白(cytotoxin-associated gene A protein,CagA)与空泡毒素将2018例血清Hp抗体阳性者分为Ⅰ型组1088例(53.9%,1088/2018)、Ⅱ型组930例(46.1%,930/2018)。Ⅰ型组与Ⅱ型组研究对象的年龄、收缩压及非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)患病率比较差异均有统计学意义(P均<0.05),而两组研究对象的性别、空腹血糖、甘油三酯、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、舒张压、体质量指数(body mass index,BMI)及腰围比较差异均无统计学意义(P均>0.05)。两组研究对象MS患病率比较差异无统计学意义[18.3%(199/1088)与19.0%(177/930),P=0.670]。多因素Logistic回归分析显示,经过年龄、性别及MS相关指标等变量校正后,不同血清Hp抗体分型与MS不存在相关性(OR=1.194,95%CI 0.842~1.693,P=0.319)。结论不同分型的Ⅰ型和Ⅱ型Hp感染与MS不存在明显相关性。Objective To explore the relationship between different types of helicobacter pylori(Hp)infection and metabolic Syndrome(MS)in healthy population.Methods The data of 4602 adults who underwent physical examination in the Space Center Hospital from January to December 2019 were collected for research,the serum Hp antibody typing was detected by immunoblotting,and the results of liver ultrasound and blood biochemical examination were collected for statistical analysis.Results Among the physical examination population,there were 2018 cases with positive serum Hp antibody and 2584 cases with negative serum Hp antibody.According to the expression of cytotoxin-associated gene A protein(CagA)and vacuolar toxin,2018 patients with positive serum Hp antibody were divided into 1088 cases in typeⅠgroup(53.9%(1088/2018))and 930 cases in typeⅡGroup(46.1%(930/2018)).There were significant differences in age,systolic blood pressure and prevalence of nonalcoholic fatty liver disease(NAFLD)between typeⅠgroup and typeⅡGroup(P<0.05).There was no significant difference in gender,fasting blood glucose,triglyceride,high-density lipoprotein cholesterol(HDL-C),diastolic blood pressure,body mass index(BMI)and waist circumference between the two groups(P>0.05).There was no significant difference in the prevalence of ms between the two groups(18.3%(199/1088))and 19.0%(177/930),P=0.670).Multivariate logistic regression analysis showed that there was no correlation.between different serum Hp antibody typing and MS(OR=1.194,95%CI 0.842-1.693,P=0.319).Conclusion Different subtypes of typeⅠand typeⅡHp infection are not distinctly associated with metabolic syndrome.

关 键 词：幽门螺杆菌 细胞毒素相关蛋白 空泡毒素 代谢综合征 

分 类 号：R573.1[医药卫生—消化系统] R589[医药卫生—内科学]