趋化因子受体CCR5在急性移植物抗宿主病防治中的研究  

Research Progress on CCR5 in acute graft versus host disease

作　　者：刘恒 吴涛 Liu Heng;Wu Tao(Department of Hematology,the 940th Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China)

机构地区：[1]联勤保障部队第九四○医院血液科,兰州730050

出　　处：《国际免疫学杂志》2021年第4期435-439,共5页International Journal of Immunology

基　　金：甘肃省自然科学基金(20JR5RA595);中央高校基本科研业务费项目(31920200011)。

摘　　要：趋化因子受体CCR5(CC chemokine receptor 5)属于β趋化因子受体,表达于人体多种免疫细胞表面,与配体特异性结合发挥募集趋化免疫细胞定向迁移的作用,在急性移植物抗宿主病(acute graft versus host disease,aGVHD)的发生过程中发挥关键作用,逐渐成为移植免疫研究的热点。文章就CCR5的结构特点、生物学功能、信号传递及CCR5在aGVHD防治中的相关研究进行讨论。CC chemokine receptor 5(CCR5)belongs to theβchemokine receptors that is expressed on a variety of immune cells.Combined with specific ligands,CCR5 plays a role in immune cell migration.It is also critical in the development of acute graft versus host disease(aGVHD)after allogeneic hematopoietic stem cell transplantation and has become a hot topic in the study of transplantation immunity.So this review is aimed to describe the structural characteristics,biological function and signal transmission of CCR5 and investigate its research progress in prophylaxis and management of aGVHD.

关 键 词：趋化因子受体 CCR5 移植物抗宿主病 异基因造血干细胞移植 

分 类 号：R457.7[医药卫生—治疗学]