长链非编码RNA与胃癌作用机制及诊断预后研究进展  

Research progress on the mechanism,diagnosis and prognosis of long non-coding RNA in gastric cancer

作　　者：向志强 郭萍 杨长青[1] 魏子白[1] Xiang Zhiqiang;Guo Ping;Yang Changqing;Wei Zibai(Department of Gastroenterology,Heping Hospital Affiliated to Changzhi Medical College,Changzhi 046000,China;Department of Central Laboratory,Changzhi Medical College,Changzhi 046000,China)

机构地区：[1]长治医学院附属和平医院消化科,山西长治046000 [2]长治医学院中心实验室,山西长治046000

出　　处：《中华消化病与影像杂志（电子版）》2021年第6期291-295,共5页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

基　　金：山西省“服务产业创新学科群建设”项目(201809);山西省高等学校科技创新项目(2020L0391)。

摘　　要：胃癌是世界常见肿瘤致死性原因之一,但由于胃癌的早期阶段临床症状不明显,大多数胃癌患者被确诊时已属晚期。因此,对胃癌研究不仅要了解发生发展的机制,而且要寻找新的早期诊断方法并建立有效的预后评估方法。长链非编码RNA (Lnc RNA)是一种重要的表观遗传学调节因子,在人类肿瘤中起着重要的作用。然而异常表达的Lnc RNA在胃癌中的作用机制尚未完全阐明。随着现代医学发展,越来越多的研究揭开了LncRNA异常表达在胃癌发生、发展和诊断预后中的机制。Gastric cancer is one of the most common causes of cancer death in the world.However,due to the lack of obvious clinical symptoms in the early stage of gastric cancer,most patients with gastriccancer were diagnosed in advanced stage.Therefore,the study of gastric cancer should not only understand themechanism of occurrence and development,but also search for new early diagnosis methods and establisheffective prognostic evaluation methods.Long non-coding RNA(lnc RNA) is an important epigenetic regulatorand plays an important role in human tumors.However,the mechanism of differentially expressed lnc RNA ingastric cancer has not been fully elucidated.With the development of modern medicine,more and more studieshave revealed the mechanism of abnormal expression of lnc RNA in the occurrence,development,diagnosis andprognosis of gastric cancer.

关 键 词：长链非编码RNA 胃癌 诊断 预后 分子标志物 

分 类 号：R735.2[医药卫生—肿瘤]