MicroRNA-342和FOXP1 mRNA在原发性肝细胞癌中的表达及临床意义  

Expression and Clinical Significance of MicroRNA-342 and FOXP1 mRNA in Hepatocellular Carcinoma

作　　者：谭国胜[1] 林方增 陈斌[2] 蔡鸿杰 罗灿峤[3] 戴海涛[1] TAN Guosheng;LIN Fangzeng;CHEN Bin;CAI Hongjie;LUO Canqiao;DAI Haitao(Department of Interventional Radiology,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Department of Hepatology Surgery,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Department of Pathology,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院放射介入科,广东广州510080 [2]中山大学附属第一医院肝外科,广东广州510080 [3]中山大学附属第一医院病理科,广东广州510080

出　　处：《临床医学工程》2021年第11期1481-1482,共2页Clinical Medicine & Engineering

基　　金：广东省自然科学基金项目(项目编号:2017A030313547)。

摘　　要：目的探讨分析MicroRNA-342(miR-342)和FOXP1 mRNA在原发性肝细胞癌(HCC)中的表达及临床意义。方法采用实时荧光定量PCR分别检测58例HCC患者的肿瘤和癌旁组织中miR-342及FOXP1 mRNA的表达水平,比较其差异并作相关性分析。结果肿瘤组织中miR-342表达水平明显低于癌旁组织,FOXP1 mRNA表达水平明显高于癌旁组织(P<0.05)。肿瘤组织中miR-342与FOXP1 mRNA的表达水平呈负相关(P<0.05)。结论在HCC中,miR-342表达下降,而FOXP1 mRNA表达升高,miR-342可能在HCC发展中发挥抑制作用。Objective To explore and analyze the expression of MicroRNA-342(miR-342)and FOXP1 mRNA in hepatocellular carcinoma(HCC)and the clinical significance.Methods The expression levels of miR-342 and FOXP1 mRNA in tumor and peritumoral tissues of 58 HCC patients were detected by real-time quantitative PCR.The difference and correlation were analyzed.Results The miR-342 expression level in tumor tissues was significantly lower than that in peritumoral tissues,and the FOXP1 mRNA expression level was significantly higher than that in peritumoral tissues(P<0.05).The expression level of miR-342 in tumor tissues was negatively correlated with FOXP1 mRNA(P<0.05).Conclusions In HCC,the miR-342 expression decreases,while the FOXP1 mRNA increases.miR-342 may be a suppressor for HCC.

关 键 词：miR-342 FOXP1 原发性肝细胞癌 表达 

分 类 号：R735.7[医药卫生—肿瘤]