强化他汀联合双联抗血小板药物治疗急性进展性脑梗死的疗效研究  

Study on the Efficacy of Enhanced Statin Combined with Dual Antiplatelet Drugs in the Treatment of Acute Progressive Cerebral Infarction

作　　者：刘少霓[1] 林楚生[1] 卢晓航[1] 张晓璇 许新炜 LIU Shaoni;LIN Chusheng;LU Xiaohang;ZHANG Xiaoxuan;XU Xinwei(3^(rd)Department of Neurology,Jieyang People's Hospital,Jieyang 522000,China)

机构地区：[1]揭阳市人民医院神经内三科,广东揭阳522000

出　　处：《临床医学工程》2021年第11期1501-1502,共2页Clinical Medicine & Engineering

基　　金：揭阳市科技计划项目(项目编号:YLWS039)。

摘　　要：目的探讨强化他汀联合双联抗血小板药物治疗急性进展性脑梗死的临床疗效。方法选取2020年1月至2021年1月我院收治的急性进展性脑梗死患者82例,随机分为对照组与研究组各41例。两组均给予脑梗死常规治疗。对照组采用阿司匹林肠溶片100 mg qd+阿托伐他汀钙片20 mg qd治疗,研究组采用阿司匹林肠溶片100 mg qd+阿托伐他汀钙片40 mg qd+硫酸氯吡格雷片75 mg qd。比较两组患者的神经功能、日常生活能力、血脂水平及相关药物不良反应。结果治疗14 d后,两组的NIHSS评分及TC、TG、LDL-C水平降低,BI及HDL-C水平升高,研究组的NIHSS评分及TC、TG、LDL-C水平低于对照组,BI及HDL-C水平高于对照组(P<0.05)。两组相关药物不良反应比较无统计学差异(P>0.05)。结论强化他汀联合双联抗血小板药物治疗急性进展性脑梗死,可显著改善患者的神经功能和日常生活能力,调节血脂水平,具有较高的治疗安全性。Objective To explore the clinical efficacy of enhanced statin combined with dual antiplatelet drugs in the treatment of acute progressive cerebral infarction.Methods 82 patients with acute progressive cerebral infarction admitted to our hospital from January 2020 to January 2021 were selected and randomly divided into control group and study group,with 41 cases in each group.Both groups received routine treatment for cerebral infarction.The control group was given aspirin enteric-coated tablets 100 mg qd+atorvastatin calcium tablets 20 mg qd,and the study group was given aspirin enteric-coated tablets 100 mg qd+atorvastatin calcium tablets 40 mg qd+clopidogrel sulfate tablets 75 mg qd.The neurological function,daily living ability,blood lipid levels,and related drug adverse reactions were compared between the two groups.Results 14 days after treatment,the NIHSS scores and the TC,TG and LDL-C levels of the two groups decreased,and the BI and HDL-C levels increased(P<0.05);The NIHSS score and the TC,TG and LDL-C levels of the study group were lower than those of the control group,and the BI and HDL-C level were higher than those of the control group(P<0.05).No statistical difference was found in the incidences of related drug adverse reactions between the two groups(P>0.05).Conclusions Intensified statin combined with dual antiplatelet drugs in the treatment of acute progressive cerebral infarction can significantly improve the neurological function and daily living ability of patients,and regulate the blood lipid levels,with higher treatment safety.

关 键 词：急性进展性脑梗死 阿托伐他汀 阿司匹林 氯吡格雷 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]