植物药相关急性肾损伤的研究进展  

Research progress of phyto medicine related acute kidney injury

作　　者：沈义兰 汪年松[1] 桂定坤[1] SHEN Yilan;WANG Niansong;GUI Dingkun(Department of Nephrology,Shanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院肾内科,上海200233

出　　处：《世界临床药物》2021年第10期819-828,共10页World Clinical Drug

摘　　要：植物药被广泛用于治疗疾病已有数千年的历史,对人类健康起到重要作用。植物药中含有多种天然化合物,活性成分相对复杂,可能会产生不同程度的不良反应。植物药中可以造成肾毒性的成分主要是马兜铃酸和其他植物生物碱。此外,植物药中的黄酮类、蒽醌类和糖苷类也可能会引起肾毒性。本文旨在论述引起肾毒性的植物药中的有毒成分,此类有毒成分的毒性机制以及防治策略,以期为植物药合理使用提供参考。Phyto medicine has been widely used to treat to diseases for thousands of years and has made great contributions to human health.Phyto medicine contains a variety of natural compounds,which have relatively complex active components and different degrees of side effects.Aristolochic acid and other plant alkaloids are the main components that can cause nephrotoxicity in phyto medicine.Furthermore,flavonoids,anthraquinones and glycosides in phyto medicine also cause nephrotoxicity.The purpose of this paper is to discuss the toxicity components in phyto medicine which cause nephrotoxicity,the toxicity mechanism of these toxicity components and the prevention and treatment strategies.

关 键 词：急性肾损伤 植物药 毒性成分 毒性机制 防治策略 

分 类 号：R692[医药卫生—泌尿科学]