血清白细胞介素-1β、淀粉样蛋白对急性脑梗死患者溶栓治疗预后的影响  

Influence of Interleukin-1β and Serum Amyloid A Protein Levels on the Prognosis of Thrombolytic Therapy in Patients with Acute Cerebral Infarction

作　　者：杨世展 YANG Shizhan(Department of Neurology,Guangshan County People’s Hospital,Xinyang 465450,China)

机构地区：[1]光山县人民医院神经内科,河南信阳465450

出　　处：《河南医学研究》2021年第33期6197-6200,共4页Henan Medical Research

摘　　要：目的探讨血清白细胞介素-1β(IL-1β)、淀粉样蛋白(SAA)对急性脑梗死(ACI)患者溶栓治疗预后的影响。方法收集2018年1月至2020年12月于光山县人民医院接受溶栓治疗3个月后预后不良的40例ACI患者的临床资料,将其纳入预后不良组,另取同期于光山县人民医院接受溶栓治疗3个月后预后良好的40例ACI患者的临床资料,将其纳入预后良好组。检测患者入院时的血清IL-1β及SAA水平,并记录患者基线资料,分析血清IL-1β及SAA水平对ACI患者溶栓治疗预后的影响。结果预后不良组血清IL-1β、SAA水平高于预后良好组,差异有统计学意义(P<0.05);经logistic回归分析结果显示,血清IL-1β、SAA水平高是ACI患者溶栓治疗预后不良的影响因素(OR>1,P<0.05);绘制受试者工作特征曲线结果显示,血清IL-1β、SAA单独及联合检测预测ACI患者溶栓治疗预后不良的曲线下面积均>0.8,具有一定预测价值,其中联合检测预测价值更高。结论血清IL-1β及SAA在ACI溶栓治疗预后不良患者中呈高表达,可能参与溶栓治疗后预后不良的发生,临床早期可通过检测血清IL-1β及SAA水平、及时实施针对性治疗方案改善患者预后。Objective To investigate the influence of serum interleukin-1β(IL-1β)and serum amyloid A protein(SAA)levels on the prognosis of thrombolytic therapy in patients with acute cerebral infarction(ACI).Methods The clinical data of 40 patients with ACI who had poor prognosis 3 months after thrombolytic therapy in Guangshan County People’s Hospital from January 2018 to December 2020 were collected and included in poor prognosis group,and the clinical data of 40 patients with ACI who had good prognosis 3 months after thrombolytic therapy in Guangshan County People’s hospital during the same period were collected and included in good prognosis group.The levels of serum IL-1βand SAA of all patients at admission were detected.The baseline data of patients were recorded.The influence of serum IL-1βand SAA levels on the prognosis of thrombolytic therapy in patients with ACI was analyzed.Results The levels of serum IL-1βand SAA of poor prognosis group were significantly higher than those of good prognosis group,and the difference was statistically significant(P<0.05).Logistic regression analysis results showed that high levels of serum IL-1βand SAA were the influencing factors of poor prognosis of thrombolytic therapy in patients with ACI(OR>1,P<0.05).The receiver operating characteristic curve was drawn,and the results showed that the area under the curve of serum IL-1βand SAA alone and cooperative detection in predicting the poor prognosis of thrombolytic therapy in patients with ACI were above 0.8,which had certain prediction value,among which the prediction value of cooperative detection was higher.Conclusion Serum IL-1βand SAA are highly expressed in ACI patients with poor prognosis after thrombolytic therapy,which may be involved in the occurrence of poor prognosis after thrombolytic therapy.The levels of serum IL-1βand SAA should be detected in the early clinical stage and targeted treatment should be implemented timely to improve the prognosis of patients.

关 键 词：急性脑梗死 白细胞介素-1Β 淀粉样蛋白 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学]