160例胃癌卵巢转移的治疗及预后因素分析  

Treatment and prognostic factors of 160 cases of gastric cancer with ovarian metastasis

作　　者：刘茜茜 李俊杰 钟丽 曲颜丽[1] LIU Qianqian;LI Junjie;ZHONG Li;QU Yanli(Department of Gastroenterology,Affiliated Cancer Hospital of Xinjiang Medical University,Xinjiang Urumqi 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院消化内科,新疆乌鲁木齐830011

出　　处：《现代肿瘤医学》2021年第24期4344-4348,共5页Journal of Modern Oncology

基　　金：新疆维吾尔自治区自然科学基金资助项目(编号:2019D01C251)。

摘　　要：目的:通过回顾性分析胃癌卵巢转移患者的临床资料,了解胃癌卵巢转移瘤切除术、患者临床病理特征与生存之间的关系,从而探索可能对其生存有益的治疗方法。方法:收集并整理2010年1月至2019年12月新疆医科大学附属肿瘤医院经组织病理学及影像学确诊的160例胃癌卵巢转移患者的资料,根据治疗方式将患者分为两组:卵巢转移瘤切除组(n=37,A组)及卵巢转移瘤未切除组(n=123,B组)。分析两组患者的临床病理特征、治疗方式与生存的关系。结果:A组的生存期明显优于B组(15.9个月vs 5.7个月,P<0.001),且此生存获益对青年女性更加明显(16.8个月vs 12.0个月,P<0.001),多因素分析显示卵巢转移瘤切除术[HR(95%CI):2.524(1.597~3.988),P<0.001]、CA125升高[HR(95%CI):0.630(0.433~0.917),P=0.016]是影响生存的独立预后因素。结论:对于胃癌卵巢转移患者,卵巢转移瘤切除术可延长生存期。转移瘤切除术、CA125水平是影响患者生存的独立预后因素。Objective:By retropsectively analyzing the clinical data of gastric cancer patients with ovarian metastases,we can explore the correlation of gastric cancer ovarian metastasis,clinicopathological characteristics and survival outcomes.In order to explore possible therapeutic strategies that may be beneficial to their survival.Methods:The way of the study was to collect and collate the data of 160 patients with gastric cancer and ovarian metastasis diagnosed by histopathology and imaging from the Cancer Hospital of Xinjiang Medical University from January 2010 to December 2019.Then the patients were divided into two groups according to the treatment method.The group of ovarian metastases resection(n=37)and the group of ovarian metastases unresection(n=123).Then analyze the clinicopathological characteristics,treatment methods and survival of the two groups of patients.Results:The overall survival was significantly increased in the ovarian metastases resection group relative to the ovarian metastases unresection group(15.9 months vs 5.7 months,P<0.001),and the survival benefit was more obvious for young women(16.8 months vs 12.0 months,P<0.001).Multivariate analysis showed that resection of ovarian metastases[HR(95%CI):2.524(1.597~3.988),P<0.001]and CA125 increased[HR(95%CI):0.630(0.433~0.917),P=0.016]were independent prognostic factors affecting survival.Conclusion:Our results suggest that for patients with ovarian metastases from gastric cancer,resection of ovarian metastases can prolong survival.Metastasis resection,CA125 level are independent prognostic factor affecting survival.

关 键 词：胃肿瘤 卵巢转移 转移瘤切除术 

分 类 号：R735.2[医药卫生—肿瘤]