预防性应用不同剂量羟考酮对妇科肿瘤剖腹手术术后急性疼痛的影响  

Effect of preventive application of different doses of oxycodone on acute pain after the operation of gynecologic tumors by laparotomy

作　　者：党莎杰 岳惠玉 王君 何元 卫文博[2] DANG Shajie;YUE Huiyu;WANG Jun;HE Yuan;WEI Wenbo(Department of Anesthesia,Shaanxi Provincial Cancer Hospital,Shaanxi Xi'an 710061,China;Department of Orthopedics,Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China)

机构地区：[1]陕西省肿瘤医院麻醉科,陕西西安710061 [2]陕西省人民医院骨科,陕西西安710068

出　　处：《现代肿瘤医学》2021年第24期4380-4383,共4页Journal of Modern Oncology

基　　金：陕西省科技厅自然科学基础研究计划项目(编号:2018JM7038)。

摘　　要：目的:评价预防性应用不同剂量羟考酮对妇科肿瘤剖腹手术术后急性疼痛的影响。方法:采用随机双盲对照研究,选取妇科肿瘤全麻剖腹手术患者60例,随机分为两组:A组(n=30)和B组(n=30)。术毕前30 min给予预防性镇痛,A组羟考酮0.10 mg/kg,B组羟考酮0.15 mg/kg。分别记录术后意识恢复时间、拔管时间、RSS躁动评分、Ramsay评分、术后1 h(T1)、术后6 h(T2)、术后12 h(T3)、术后24 h(T4)的静态NRS评分及术后24 h的不良反应。结果:B组患者与A组相比,RSS躁动评分和T1、T2的静态NRS评分低,差异均有统计学意义(P<0.05)。两组患者的意识恢复时间、拔管时间、Ramsay评分和24 h内的不良反应均无统计学差异。结论:预防性应用0.15 mg/kg盐酸羟考酮注射液能够有效减轻妇科肿瘤剖腹手术术后急性疼痛的程度,且不影响患者术后苏醒,安全性较高。Objective:To evaluate the effect of preventive application of different doses of oxycodone on acute pain after the operation of gynecologic tumors by laparotomy.Methods:A randomized,double-blind research was conducted.60 patients on laparotomy for gynecologic tumor after general anesthesia were randomly divided into two groups:Group A(n=30)and Group B(n=30).Patients in Group A received 0.10 mg/kg oxycodone,whereas patients in Group B received 0.15 mg/kg oxycodone 30 min before the end of operation.The time of consciousness recovery and extubation,RSS restlessness score,Ramsay score,numerical rating scale(NRS)at rest in 1 h after surgery(T;),6 h after surgery(T;),12 h after surgery(T;),24 h after surgery(T;)and the incidence of adverse complications were recorded.Results:Compared with Group A,patients in Group B showed lower RSS restlessness score and NRS score at rest in T;and T;(P<0.05).There was no difference in time of consciousness recovery and extubation,Ramsay score and incidence of side effects in 24 h after surgery of both groups.Conclusion:Intravenous injection of 0.15 mg/kg oxycodone 30 min before the end of operation can effectively reduce postoperative pain,does not affect the recovery of patients,and does not increase adverse complications in patients on the operation of gynecologic tumors by laparotomy.

关 键 词：羟考酮 舒芬太尼 妇科肿瘤剖腹手术 预防性镇痛 

分 类 号：R730.56[医药卫生—肿瘤]