中国药典与国外药典对0.1 mol/L硫代硫酸钠滴定液的标定比较与分析  

Comparison and Analysis of the Calibration of 0.1mol/L Sodium Thiosulfate Volumetric Solution between Chinese Pharmacopoeia and Foreign Pharmacopoeia

作　　者：林婷婷 Lin Tingting(Guangdong Institute for Drug Control,Guangzhou 510000,China)

机构地区：[1]广东省药品检验所,广东广州510000

出　　处：《广东化工》2021年第19期46-47,共2页Guangdong Chemical Industry

摘　　要：目的:比较分析中国药典、美国药典和日本药典分别对0.1 mol/L硫代硫酸钠滴定液的配制与标定要求的异同,通过对比分析不同方法标定的结果,对其进一步应用有一定的指导意义。方法:采用容量分析法;以重铬酸钾和碘酸钾为基准物,淀粉指示液为指示剂,用0.1 mol/L硫代硫酸钠滴定液滴定至终点。以基准物取样量和标定中滴定液用量,计算出F值。结果:在室温20℃,根据《中国药典》2020版、《美国药典》43版和《日本药典》17版标定F值分别为0.1014、0.1016、0.1014。Objective:To compare and analyze the similarities and differences in the preparation and calibration requirements of 0.1 mol/L sodium thiosulfate volumetric solution in the Chinese Pharmacopoeia,the United States Pharmacopoeia and the Japanese Pharmacopoeia,and to compare and analyze the calibration results of different methods to provide certain guidance for its further application significance.Methods:The volumetric analysis method was used;potassium dichromate and potassium iodate were used as benchmarks,starch indicator solution was used as indicator,and 0.1 mol/L sodium thiosulfate volumetric Solution was used to titrate to the end point.Calculate the F value based on the sample volume of the reference substance and the volume of the titrant in the calibration.Results:At a room temperature of 20℃,the F values calibrated according to the 2020 edition of the Chinese Pharmacopoeia,USP43 and JP17 were 0.1014,0.1016,and 0.1014,respectively.

关 键 词：中国药典 美国药典 日本药典 硫代硫酸钠滴定液 F值 

分 类 号：TQ[化学工程]