毒物代谢过程的调节对宣威市肺癌高发的影响  

The Effect of Regulation of Toxicant Metabolism on High Incidence of Lung Cancer in Xuanwei Area

作　　者：吴爽爽 王娅洁 付玉 储江 孔祥阳 WU Shuangshuang;WANG Yajie;FU Yu;CHU Jiang;KONG Xiangyang(Genetics and Pharmacogenomics Laboratory,Medical School,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]昆明理工大学医学院,疾病与药物遗传实验室,昆明650500

出　　处：《中国细胞生物学学报》2021年第10期2071-2077,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81760258);昆明理工大学省级人培项目(批准号:KKSY201660006);云南省“万人计划”青年拔尖人才专项资助的课题。

摘　　要：中国云南省宣威市是肺部疾病(特别是肺癌和慢性阻塞性肺病)的高发区域,并且其女性肺癌的死亡率居全国首位,因此了解该地区肺癌高发的原因对当地居民尤为重要。肺癌的发生往往是环境与遗传因素共同作用的结果,该地区长期以烟煤为生活燃料,烟煤燃烧和吸烟都会释放大量的多环芳烃(polycyclic aromatic hydrocarbons,PAHs)。PAHs在机体内的代谢过程涉及到多种毒物代谢酶的作用,而毒物代谢酶的基因多态性会影响个体对肺癌的易感性。该文的目的在于探究多环芳烃在机体内的代谢、毒物代谢酶基因的多态性以及遗传易感性对宣威市肺癌高发的影响。Xuanwei city,Yunnan province,China,has a high incidence of lung diseases(especially lung cancer and chronic obstructive pulmonary disease),and has the highest mortality rate of female lung cancer in the country.Therefore,it is particularly important for local residents to understand the causes of the high incidence of lung cancer in this area.The occurrence of lung cancer is often the result of the joint action of environmental and genetic factors.In this area,bituminous coal has been used as living fuel for a long time.Both the burning and smoking of bituminous coal will release a large amount of PAHs(polycyclic aromatic hydrocarbons).The metabolic process of PAHs in the body involves in the role of various toxic metabolic enzymes,and the gene polymorphism of toxic metabolic enzymes will affect the susceptibility of individuals to lung cancer.The purpose of this paper is to explore the polycyclic aromatic hydrocarbons metabolism in the body,the polymorphism of toxic metabolic enzymes gene and the influence of genetic susceptibility on the high incidence of lung cancer in Xuanwei area.

关 键 词：毒物代谢酶 基因多态性 遗传易感性 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]