iCare iC100与Corvis ST测量眼压的重复性和一致性比较  

Repeatability and Consistency of iCare iC100 and Corvis ST Intraocular Pressure Measurements

作　　者：郑伊苹 赵平 刘瑞 彭悦 Yiping Zheng;Ping Zhao;Rui Liu;Yue Peng(Aier School of Ophthalmology,Central South University,Changsha 410083,China;Department of Glaucoma,Shenyang Aier Eye Hospital,Shenyang 110000,China)

机构地区：[1]中南大学爱尔眼科学院,长沙410083 [2]沈阳爱尔眼视光医院青光眼科,110000

出　　处：《中华眼视光学与视觉科学杂志》2021年第10期745-751,共7页Chinese Journal Of Optometry Ophthalmology And Visual Science

摘　　要：目的: 比较iCare iC100回弹式眼压计(iC100)和Corvis ST角膜生物力学分析仪(CST)测量眼压的重复性和一致性, 分析iC100测量的眼压与角膜生物力学特性的关系。方法: 系列病例研究。本研究于2020年6─10月在沈阳爱尔眼视光医院职工或白内障患者中招募志愿者50例(50眼), 其中健康眼23例(23眼), 白内障患者27例(27眼)。分别使用CST、iC100和Goldmann压平眼压计(GAT)测量眼压, 每只眼睛连续测量3次, 各眼压计测量眼压值分别记为bIOP、IOPiC100和IOPGAT。角膜生物力学特征参数和中央角膜厚度(CCT)采用CST进行测量。使用组内相关系数(ICC)评价眼压计的重复性;使用单因素方差分析及Bland-Altman分析比较眼压计的一致性;使用Pearson相关系数及简单线性回归分析各眼压计与CCT的关系, 使用Pearson相关系数或非参数Spearman分析角膜生物力学参数与3种眼压计测量值的关系, 使用多重线性回归分析iC100测量值与角膜生物力学特性的关系。结果: bIOP、IOPGAT和IOPiC100分别为(14.79±1.73)、(14.46±2.00)、(14.18±2.80)mmHg, 三者差异无统计学意义。CST、GAT和iC100的眼压测量值可重复性较好(ICC=0.729、0.973、0.923, P<0.001)。Bland-Altman分析表明, IOPiC100和bIOP、IOPGAT和IOPiC100、IOPGAT和bIOP之间具有良好的一致性。IOPGAT、IOPiC100与CCT均存在正相关关系(R2=0.122, P=0.013;R2=0.183, P=0.002), bIOP与CCT无相关性。bIOP、IOPGAT与IOPiC100均与第1次压平时间(TA1)、第1次压平时的硬度参数(SP-A1)、第2次压平长度(LA2)、第2次压平速度(VA2)呈正相关(均P<0.05);与第1次压平速度(VA1)、第2次压平时间(TA2)、最大压陷时的变形幅度(HC-DA)、形变比例(DAR)、综合半径(IR)呈负相关(均P<0.05);与最大压陷的时间(HC-time)不相关。多元线性回归模型具有统计学意义(F=26.177, P<0.001, 调整R2=0.507), 纳入模型的2个自变量DAR、TA2对IOPiC100的影响均有统计学意义(t=-4.341, P<0.001;t=-2.Objective:To analyze the repeatability of the iCare iC100 rebound tonometer(iC100)and the corneal visualization Scheimpflug technology(CST),to evaluate the consistency of the results of CST,iC100 and Goldmann applanation tonometer(GAT),and to analyze the relationship between iC100 tonometer and corneal biomechanical properties.Methods:This was a case series study that involved 50 healthy volunteers(50 eyes)in Shenyang Aier Eye Hospital from June to October 2020.iC100 and GAT were used to measure IOP,and each eye was measured three times.Corneal biomechanical parameters,central corneal thickness(CCT)and corneal biomechanical corrected intraocular pressure(bIOP)were obtained by CST.The intra-group correlation coefficient(ICC)was used to evaluate the repeatability of the three tonometers.The consistency of the tonometers was described by Bland-Altman analysis and one-way ANOVA.Pearson correlation coefficient and simple linear regression were used to analyze the relationship between each tonometer and CCT.Pearson correlation coefficient or nonparametric Spearman analysis was used to analyze the relationship between corneal biomechanical parameters and the three IOP measurment results,a multivariate linear regression analysis was used to analyze the relationship between iC100 and corneal biomechanical properties.Results:All tonometers showed similar IOP results(bIOP:14.79±1.73 mmHg;IOPGAT:14.46±2.00 mmHg;IOPiC100:14.18±2.80 mmHg).The IOP measurements of Corvis ST,iC100 and GAT were reproducible(ICC=0.729,0.973,0.923,P<0.001).Bland-Altman analysis showed that there was good consistency between IOPiC100 and bIOP,IOPiC100 and IOPGAT,bIOP and IOPGAT.With the exception of bIOP,IOPGAT and IOPiC100 were both affected by CCT(R2=0.122,P=0.013;R2=0.183,P=0.002,respectively).The IOP measurements of CST,GAT and iC100 were positively correlated with the first applanation length(TA1),stiffness parameter at first applanation(SP-A1),second applanation length(LA2),and second applanation velocity(VA2)(P<0.05).IOP measurements were n

关 键 词：眼压 回弹式眼压计 角膜生物力学特性 重复性 一致性 

分 类 号：R775[医药卫生—眼科]