安肠组方保留灌肠对大肠湿热型急性放射性肠炎患者生存质量及免疫微环境的影响分析  

Analysis of quality of life and its influence on immune microenvironment in patients with acute radiation enteritis of Damp-Heat type of large intestine treated by retention enema with Anchang Zufang

作　　者：何新颖[1] 高志远[2] 梁伟 孙月红 胡秀茹[1] 杨文博 贾大鹏 吴超 孙云川[1] HE Xinying;GAO Zhiyuan;LIANG Wei;SUN Yuehong;HU Xiuru;YANG Wenbo;JIA Dapeng;WU Chao;SUN Yunchuan(Department of Radiotherapy,Cangzhou Hospital of Intergrated Traditional Chinese and Western Medicine,Cangzhou,061000,China;Department of Spleen Stomach and Liver Disease,Cangzhou Hospital of Intergrated Traditional Chinese and Western Medicine)

机构地区：[1]沧州中西医结合医院放化疗一科,河北沧州061000 [2]沧州中西医结合医院脾胃肝病科

出　　处：《中国中西医结合消化杂志》2021年第11期787-790,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：河北省中医药管理局课题(No:2022221)。

摘　　要：目的:分析大肠湿热型急性放射性肠炎患者用安肠组方治疗前后的生存质量及对患者免疫微环境的影响。方法:以2014年11月—2020年11月收治的68例大肠湿热型急性放射性肠炎患者为研究对象,给予患者安肠组方为基本方保留灌肠,2次/d,14 d为1个疗程。比较患者治疗前后的维也纳直肠镜评分(VAS),T淋巴细胞亚群CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)值,癌症患者生命质量测定量表(QLQ-C30)评分,评价安肠组方对患者生存质量及免疫微环境的影响。结果:应用安肠组方治疗后,大肠湿热型急性放射性肠炎患者的VAS评分明显降低,生存质量明显提高(P<0.05);在免疫学指标方面,T淋巴细胞亚群CD_(3)^(+)、CD_(4)^(+)、CD_(8)^(+)值较治疗前提高,差异有统计学意义(P<0.001);与治疗前比较,患者的QLQ-C30量表总健康状态、躯体功能、情绪功能、社会功能优于治疗前,差异有统计学意义(P<0.05)。结论:安肠组方可通过调节T淋巴细胞亚群进一步改善大肠湿热型急性放射性肠炎患者的免疫微环境状态,从而起到改善患者症状、提高生活质量的效果。Objective:To analyze the quality of life of patients with acute radiation enteritis of large intestine Damp-Heat type before and after treatment with Anchang Zufang and the impact on the patients’immune microenvironment.Methods:Sixty eight patients with acute radiation enteritis of Damp-Heat type of large intestine who were admitted from November 2014 to November 2020 were taken as the research object,and the patients were given Anchang Zufang as the basic prescription retention enema,2 times per day,14 days as a course of treatment.Compare patients’Vienna rectoscopy score(VAS)before and after treatment,T lymphocyte subgroup CD_(3)^(+),CD_(4)^(+),CD_(8)^(+)value,cancer patient quality of life measurement scale(QLQ-C30)score,evaluate the effect of Anchang Zufang on the patients’quality of life and immune to the influence of the microenvironment.Results:After treatment with Anchang Zufang,the VAS score of patients with acute radiation enteritis of large intestine Damp-Heat type was significantly reduced,and the quality of life was significantly improved(P<0.05);In terms of immunological indicators,the CD_(3)^(+),CD_(4)^(+),and CD_(8)^(+)values of T lymphocyte subsets compared with before treatment,the difference is statistically significant(P<0.001);Compared with before treatment,the patients’QLQ-C30 scales overall health status,physical function,emotional function,and social function are better than before treatment,and the differences were statistically significant(P<0.05).Conclusion:Anchang Zufang can further improve the immune microenvironment status of patients with Damp-Heat type of acute radiation enteritis of the large intestine by regulating T lymphocyte subsets,there by improving the symptoms of patients and improving the quality of life.

关 键 词：安肠组方 急性放射性肠炎 生存质量 免疫微环境 

分 类 号：R730.5[医药卫生—肿瘤]