ADC值在高级别胶质瘤与中枢神经系统淋巴瘤中的比较  

作　　者：吴玲 王冬女[1] 朱华勇[1] 李杨飞[1] 李欣[1] 庞坚信[1] 郑珂[1] 胡安夏 季文斌[1] 

机构地区：[1]浙江省台州医院,浙江临海317000

出　　处：《浙江临床医学》2021年第11期1581-1583,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省医药卫生科技计划项目(2019KY777)。

摘　　要：目的探讨ADC值在高级别胶质瘤(HGG)与原发性中枢神经系统淋巴瘤(PCNSL)鉴别诊断中的价值方法回顾性分析经病理证实的10例HGG患者(12个病灶)和10例PCNSL患者(20个病灶),分析两组MRI平扫、强化特点,并测量肿瘤实质区的ADC值,比较PCNSL与HGG囊变数量、出血、强化特点及ADC值的差异结果HGG组12个病灶均发生囊变,6个病灶有点状或片状出血,强化方式以花环样强化为主,部分呈片状不均匀强化。PCNSL组20个病灶,3例囊变坏死,未见出血,强化方式均明显均匀强化,可见“握拳征”。HGG组肿瘤平均ADC值为(1.02±0.30)×10^(-3)mm^(2)/s,PCNSL组肿瘤平均ADC值为(0.69±0.08)×10^(-3)mm^(2)/s,差异有统计学意义(P<0.05)结论ADC值定量分析联合MRI形态特点、强化方式对GBM与PCNSL的鉴别诊断有重要临床意义。Objective To explore the value of ADC value in the differential diagnosis of high-grade glioma(HGG)and primary central nervous system lymphoma(PCNSL).Methods This was a retrospective study.The two groups were 10 HGG patients(12 lesions)and 10 PCNSL patients(20 lesions)confimied by pathology.Conventional magnetic resonance imaging,contrast enhancement and DWI were performed on the patients.The characteristics of cystic degeneration,hemorrhage,enhancement of the tumor and DWI signal,ADC values of the two groups were compared by using T-test and Fisher exact Test.Results In the HGG group,12 lesions,all showed cystic change,6 lesions showed bleeding.Contrast enhancement was homogeneous or heterogeneous.Of the 20 lesions in the PCNSL group,3 cases showed cystic change,and no bleeding was seen.Contrast enhancement was homogeneous,and some showed a"Clenched-Fist"sign.The average ADC value of the tumor parenchyma in the HGG group was(1.02±0.30)×10^(-3)mm^(2)/,and the average ADC value of the tumor parenchyma in the PCNSL group was(0.69±0.08)×10^(-3)mm^(2)/.There was a significant difference in the average ADC value of the tumor parenchym«i between the two groups Significance(t value=3.71,P<0.05).Conclusion ADC value combined with Conventional MRI and contrast enhancement characteristics is more helpful for the differential diagnosis of GBM and PCNSL.

关 键 词：表观扩散系数 高级别胶质瘤 中枢神经系统淋巴瘤 

分 类 号：R73[医药卫生—肿瘤]