Multi-mechanical waves against Alzheimer’s disease pathology:a systematic review  

作　　者：Francisca Monteiro Ioannis Sotiropoulos Óscar Carvalho Nuno Sousa Filipe S.Silva 

机构地区：[1]Center for Microelectromechanical Systems(CMEMS),University of Minho,Campus Azurém,4800-058 Guimarães,Portugal [2]Life and Health Sciences Research Institute(ICVS),Medical School,University of Minho,Campus Gualtar,4710-057 Braga,Portugal [3]ICVS/3B’s-PT Government Associate Laboratory,Braga/Guimarães,Portugal [4]Institute of Biosciences&Applications NCSR“Demokritos”,Athens,Greece

出　　处：《Translational Neurodegeneration》2021年第3期459-486,共28页转化神经变性病（英文）

基　　金：This systematic review was supported by FCT(Fundação para a Ciência e Tecnologia)through the grant with reference SFRH/BD/09375/2020,and in the scope of the projects UIDB/04436/2020,UIDP/04436/2020,and NORTE-01-0145-FEDER-000023;funded by the European Fund for Regional Development(FEDER)of the Operational Programme for Competitiveness and Internationalization(POCI),by Portugal 2020。

摘　　要：Alzheimer’s disease(AD)is the most common cause of dementia,afecting approximately 40 million people worldwide.The inefectiveness of the available pharmacological treatments against AD has fostered researchers to focus on alternative strategies to overcome this challenge.Mechanical vibrations delivered in diferent stimulation modes have been associated with marked improvements in cognitive and physical performance in both demented and nondemented elderly.Some of the mechanical-based stimulation modalities in eforts are earlier whole-body vibration,transcranial ultrasound stimulation with microbubble injection,and more recently,auditory stimulation.However,there is a huge variety of treatment specifcations,and in many cases,conficting results are reported.In this review,a search on Scopus,PubMed,and Web of Science databases was performed,resulting in 37 papers.These studies suggest that mechanical vibrations delivered through diferent stimulation modes are efective in attenuating many parameters of AD pathology including functional connectivity and neuronal circuit integrity defcits in the brains of AD patients,as well as in subjects with cognitive decline and non-demented older adults.Despite the evolving preclinical and clinical evidence on these therapeutic modalities,their translation into clinical practice is not consolidated yet.Thus,this comprehensive and critical systematic review aims to address the most important gaps in the reviewed protocols and propose optimal regimens for future clinical application.

关 键 词：Alzheimer’s disease Auditory stimulation Mechanical vibrations ULTRASOUNDS Whole-body vibration 

分 类 号：R749.16[医药卫生—神经病学与精神病学]