乳腺癌组织FOXP3、HMGA2、RASAL2的表达及与临床病理特征和预后的关系  

The Expression of FOXP3,HMGA2 and RASAL2 in Breast Cancer Tissues and Their Relationship with Clinicopathological Features and Prognosis

作　　者：李会芳 侯永强[1] 王明军[1] 陈涛[2] 刘金彪[1] LI Hui-fang;HOU Yong-qiang;WANG Ming-jun;CHEN Tao;LIU Jin-biao(Third Department of General Surgery,The First Affiliated Hospital of Henan University of science and technology/School of Clinical Medicine,Henan University of Science and Technology,Luoyang,Henan,471003,China;Department of General Surgery,Zhengzhou People's Hospital/People's Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,450003,China)

机构地区：[1]河南科技大学第一附属医院/河南科技大学临床医学院普外三科,河南洛阳471003 [2]郑州人民医院/河南中医药大学人民医院普外科,河南郑州450003

出　　处：《现代生物医学进展》2021年第20期3959-3964,共6页Progress in Modern Biomedicine

基　　金：河南省医学科技攻关计划项目(201504015)。

摘　　要：目的:探讨乳腺癌组织叉头框蛋白P3(FOXP3)、高迁移率族蛋白A2(HMGA2)、大鼠肉瘤蛋白活化因子2(RASAL2)的表达及其与临床病理特征和预后的关系。方法:选取2014年6月至2015年6月期间我院收治的102例乳腺癌患者作为研究对象。检测乳腺癌组织以及癌旁组织中FOXP3、HMGA2、RASAL2表达,分析FOXP3、HMGA2、RASAL2表达与临床病理参数的相关性。Kaplan-Meier生存曲线分析不同FOXP3、HMGA2、RASAL2表达患者总生存率的差异。Cox比例风险回归模型分析乳腺癌患者预后的影响因素。结果:与癌旁组织相比,乳腺癌组织中FOXP3、HMGA2阳性表达率升高,而RASAL2阳性表达率降低(P<0.05)。FOXP3、HMGA2、RASAL2表达均与TNM分期和淋巴结转移相关(P<0.05)。FOXP3、HMGA2阳性患者的生存率明显低于FOXP3、HMGA2阴性患者,RASAL2阳性患者的生存率明显高于RASAL2阴性患者(P<0.05)。TNM分期Ⅲ期、FOXP3阳性表达、HMGA2阳性表达是影响乳腺癌患者预后的危险因素(P<0.05),而RASAL2阳性表达是乳腺癌患者预后的保护因素(P<0.05)。结论:乳腺癌组织中FOXP3和HMGA2阳性表达率升高,而RASAL2阳性表达率降低,FOXP3和HMGA2阳性表达以及RASAL2阴性表达与乳腺癌患者TNM分期、淋巴结转移相关,并且是患者预后不良的影响因素。Objective:To investigate the expression of forkhead box P3(FOXP3),high mobility group protein A2(HMGA2)and ras protein activator like 2(RASAL2)in breast cancer tissues and their relationship with clinicopathological features and prognosis.Methods:102 cases of breast cancer patients who were treated in our hospital from June 2014 to June 2015 were selected as the research objects.The expressions of FOXP3,HMGA2 and RASAL2 in breast cancer tissues and adjacent tissues were detected.The correlation of expressions of FOXP3,HMGA2 and RASAL2 with clinicopathological parameters was analyzed.Kaplan-Meier survival curve was used to analyze the difference of the overall survival rate of patients with different expressions of FOXP3,HMGA2 and RASAL2.Cox proportional hazard regression analysis of prognostic factors in breast cancer patients.Results:Compared with adjacent tissues,the positive expression rates of FOXP3 and HMGA2 in breast cancer tissues were increased,while the positive expression rate of RASAL2 was decreased(P<0.05).The expressions of FOXP3,HMGA2 and RASAL2 were all correlated with TNM stage and lymph node metastasis(P<0.05).The survival rate of FOXP3 and HMGA2 positive patients were significantly lower than those of FOXP3 and HMGA2 negative patients,and the survival rate of RASAL2 positive patients was significantly higher than that of RASAL2 negative patients(P<0.05).TNM stageⅢ,FOXP3 positive expression,HMGA2 positive expression were the risk factor affecting the prognosis of breast cancer patients(P<0.05),the positive expression of RASAL2 was a protective factor for the prognosis of breast cancer patients(P<0.05).Conclusion:The positive expression rates of FOXP3 and HMGA2 in breast cancer tissues are increased,while the positive expression rates of RASAL2 is decreased.The positive expression of FOXP3 and HMGA2 and the negative expression of RASAL2 were correlated with TNM stage and lymph node metastasis in breast cancer patients,and are the influencing factors for poor prognosis of the patients.

关 键 词：乳腺癌 叉头框蛋白P3 高迁移率族蛋白A2 大鼠肉瘤蛋白活化因子2 预后 病理特征 因素 

分 类 号：R737.9[医药卫生—肿瘤]