胃复春片联合兰索拉唑肠溶片对慢性萎缩性胃炎患者血清胃肠激素、炎症因子及免疫功能的影响  

Effect of Weifuchun Tablet Combined with Lansoprazole Enteric-coated Tablet on Serum Gastrointestinal Hormones,Inflammatory Factors and Immune Function in Chronic Atrophic Gastritis

作　　者：强薇[1] 贾如冰[1] 毕玮 贾伟[1] 马超 QIANG Wei;JIA Ru-bing;BI Wei;JIA Wei;MA Chao(Department of Gastroenterology,Beijing Rehabilitation Hospital Affiliated to Capital Medical University,Beijing,100144,China;Department of Gastroenterology,Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine,Beijing,100700,China)

机构地区：[1]首都医科大学附属北京康复医院消化科,北京100144 [2]北京中医药大学东直门中医院消化科,北京100700

出　　处：《现代生物医学进展》2021年第21期4066-4069,4162,共5页Progress in Modern Biomedicine

基　　金：北京市科技计划项目(Z17110004017102)。

摘　　要：目的:胃复春片联合兰索拉唑肠溶片对慢性萎缩性胃炎(CAG)患者血清胃肠激素、炎症因子及免疫功能的影响。方法:选取62例CAG患者,根据门诊挂号奇偶性分为对照组(n=31,兰索拉唑肠溶片治疗)和研究组(n=31,胃复春片联合兰索拉唑肠溶片治疗)。比较两组患者疗效、胃肠激素[胃泌素(GAS)、胃动素(MTL)]、炎症因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)]、免疫功能及不良反应。结果:研究组治疗2个月后的总有效率为87.10%(27/31),高于对照组的64.52%(20/31),差异有统计学意义(P<0.05)。治疗2个月后,研究组hs-CRP、TNF-α、IL-6、GAS、CD8P低于对照组,MTL、CD4P、CD4~+/CD8~+高于对照组(P<0.05)。两组不良反应发生率对比未见明显差异(P>0.05)。结论:胃复春片联合兰索拉唑肠溶片治疗CAG疗效确切,可有效改善机体胃肠激素、炎症因子水平及免疫功能,且安全可靠,具有一定应用价值。Objective:The effect of Weifuchun tablets combined with Lansoprazole Enteric-coated tablet on serum gastrointestinal hormones,inflammatory factors and immune function in chronic atrophic gastritis(CAG).Methods:62 CAG patients admitted to our hospital from May 2018 to August 2019 were selected,and they were divided into control group(n=31,treated with Lansoprazole Entericcoated tablet)and study group(31,treated with Lansoprazole Enteric-coated tablet combined Weifuchun tablet)by the parity of the mantissa of the out-patient registration number.The curative effect,gastrointestinal hormones[gastrin(GAS),motilin(MTL)],inflammatory factors[high sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],immune function and adverse reactions of the two groups were compared.Results:The total effective rate of the study group was 87.10%(27/31),which was higher than 64.52%(20/31)of the control group at 2 months after treatment(P<0.05).2 months after treatment,hs-CRP,TNF-α,IL-6,GAS,CD8+of the study group was lower than those of the control group(P<0.05).2 months after treatment,MTL,CD4+and CD4+/CD8+were higher than those of the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Lansoprazole Enteric-coated tablet combined with Weifuchun tablet in the treatment of CAG has definite curative effect,can effectively improve gastrointestinal hormones,inflammatory factors and immune function,and does not increase the incidence of adverse reactions,which is safe and reliable with certain application value.

关 键 词：胃复春片 兰索拉唑肠溶片 慢性萎缩性胃炎 胃肠激素 炎症因子 免疫功能 

分 类 号：R573.32[医药卫生—消化系统]