越鞠丸联合子午流注开穴疗法对功能性消化不良伴焦虑抑郁患者血清胃泌素、胃蛋白酶原的影响  

Effect of Yueju Pill Combined with Ziwuliuzhu Point Opening Therapy on Serum Gastrin and Pepsinogen in Patients with Functional Dyspepsia and Anxiety and Depression

作　　者：王萍[1] 王黎[2] 牛崇峰[1] 秦英[3] 杨君[4] WANG Ping;WANG Li;NIU Chong-feng;QIN Ying;YANG Jun(Department of Traditional Chinese Medicine,Nanjing Hospital Affiliated to Nanjing Medical University/Nanjing First Hospital,Nanjing,Jiangsu,210000,China;Department of Gastroenterology,Nanjing Hospital Affiliated to Nanjing Medical University/Nanjing First Hospital,Nanjing,Jiangsu,210000,China;Department of Endocrine,Dongzhimen Hospital Affiliated to Beijing University of Traditional Chinese Medicine,Beijing,100700,China;Preventive Treatment Center,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing,100010,China)

机构地区：[1]南京医科大学附属南京医院/南京市第一医院中医科,江苏南京210000 [2]南京医科大学附属南京医院/南京市第一医院消化内科,江苏南京210000 [3]北京中医药大学附属东直门医院内分泌科,北京100700 [4]首都医科大学附属北京中医医院治未病中心,北京100010

出　　处：《现代生物医学进展》2021年第19期3680-3684,共5页Progress in Modern Biomedicine

基　　金：江苏省自然科学基金青年基金项目(BK20160135)。

摘　　要：目的:探讨越鞠丸联合子午流注开穴疗法治疗功能性消化不良(FD)伴焦虑抑郁的疗效及对血清胃泌素、胃蛋白酶原的影响。方法:选取2017年7月~2020年7月期间南京市第一医院和首都医科大学附属北京中医医院收治的150例FD伴焦虑抑郁患者,以随机数字表法分为对照组(n=75,常规西医治疗)和研究组(n=75,对照组基础上给予越鞠丸联合子午流注开穴疗法治疗)。疗程均为4周。对比两组治疗4周后的临床疗效,对比两组治疗前、治疗4周后的中医证候积分、焦虑抑郁情况、血清胃泌素和胃蛋白酶原水平。结果:对照组的临床总有效率为76.00%(57/75),低于研究组的92.00%(69/75)(P<0.05)。治疗4周后,两组主证(脘腹胀满、胃痛、食欲不振)、次证(胁肋胀痛、嗳气泛酸、恶心呕吐、烦躁太息、神疲乏力、口苔黏腻、大便稀溏)积分均降低,且研究组较对照组低(P<0.05)。治疗4周后,两组Zung抑郁自评量表(SDS)、Zung焦虑自评量表(SAS)评分均降低,且研究组较对照组低(P<0.05)。治疗4周后,两组血清胃泌素、胃蛋白酶原1、胃蛋白酶原2水平均升高,且研究组较对照组高(P<0.05)。结论:采用子午流注开穴疗法联合越鞠丸治疗FD伴焦虑抑郁患者,可有效改善患者焦虑抑郁状态和临床症状,提高血清胃泌素和胃蛋白酶原水平,明显提升临床疗效。Objective:To investigate the curative effect of Yueju pill combined with Ziwuliuzhu point opening therapy in the treatment of functional dyspepsia(FD)with anxiety and depression and its influence on serum gastrin and pepsinogen.Methods:150 cases of functional dyspepsia with anxiety and depression admitted to the Nanjing First Hospital and Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University from July 2017 to July 2020 were selected.They were randomly divided into control group(n=75,conventional western medicine treatment)and study group(n=75,Yueju pill combined with Ziwuliuzhu point opening therapy on the basis of the control group)by random number table method.The course of treatment was 4 weeks.The clinical efficacy of the two groups after 4 weeks of treatment was compared,anxiety and depression,serum gastrin and pepsinogen levels and traditional Chinese medicine syndrome scores were compared between the two groups before and after 4 weeks of treatment.Results:The clinical total effective rate of the control group was 76.00%(57/75),which was lower than 92.00%(69/75)of the study group(P<0.05).After 4 weeks of treatment,the scores of main syndromes(abdominal distension,stomachache,anorexia),secondary syndromes(costal distension,belching,pantothenic acid,nausea and vomiting,dysphoria,fatigue,greasy mouth coating,loose stool)scores of the two groups were decreased,and the study group was lower than the control group(P<0.05).After 4 weeks of treatment,the scores of Zung self rating Depression Scale(SDS)and Zung self rating Anxiety Scale(SAS)in the two groups were decreased,and the study group was lower than the control group(P<0.05).After 4 weeks of treatment,serum gastrin,pepsinogen-1 and pepsinogen-2 levels in the two groups were increased,and the study group was higher than the control group(P<0.05).Conclusion:Ziwuliuzhu acupoint opening therapy combined with Yueju pill in the treatment of FD patients with anxiety and depression can effectively improve the anxiety and depressi

关 键 词：越鞠丸 子午流注开穴疗法 功能性消化不良 焦虑抑郁 胃泌素 胃蛋白酶原 

分 类 号：R573[医药卫生—消化系统] R574[医药卫生—内科学]