超声造影联合超声弹性成像组织弥散定量分析在乳腺癌诊断中的应用  

Application of Ultrasound Contrast Combined with Ultrasound Elastography Quantitative Analysis of Tissue Diffusion in the Diagnosis of Breast Cancer

作　　者：周成香[1] 刘亚斌[2] 赵林[1] 苏红[1] 梁艳[1] ZHOU Cheng-xiang;LIU Ya-bin;ZHAO Lin;SUHong;LIANG Yan(Department of Ultrasound,The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan,610500,China;Department of Radiology,The First Affiliated Hospital of Chengdu Medical College,Chengdu,Sichuan,610500,China)

机构地区：[1]成都医学院第一附属医院超声科,四川成都610500 [2]成都医学院第一附属医院放射科,四川成都610500

出　　处：《现代生物医学进展》2021年第19期3783-3786,3791,共5页Progress in Modern Biomedicine

基　　金：四川省医学科研课题计划项目(Q18005)。

摘　　要：目的:探讨超声造影联合超声弹性成像组织弥散定量分析在乳腺癌诊断中的应用价值。方法:2019年1月至2020年5月选择在本院诊治的乳腺肿瘤患者148例,所有患者都给予超声造影联合超声弹性成像组织弥散定量分析,记录影像学特征。结果:在148例患者中,病理诊断为乳腺癌32例(恶性组),良性乳腺肿瘤116例(良性组)。良性组与恶性组的超声病灶形状、边缘、回声、微钙化等特征对比差异有统计学意义(P<0.05)。恶性组的超声造影增强模式、强度与良性组对比差异都有统计学意义(P<0.05)。恶性组的造影灌注参数曲线下面积(Area under the curve,AUC)、峰值强度(Peak intensity,PI)、上升支斜率(Wash in slope,WIS)值都高于良性组,达峰时间(Time To Peak,TTP)值低于良性组,对比差异都有统计学意义(P<0.05)。恶性组的组织弥散定量参数蓝色区域面积百分比(area ratio,%AREA)低于良性组,标准差(standard deviation,SD)、应变均值(mean,MEAN)值高于良性组,对比差异都有统计学意义(P<0.05)。结论:超声造影联合超声弹性成像组织弥散定量分析在乳腺癌诊断中的应用作为一种经济快捷、实时无创、重复性好的检查方法,能够定量评估乳腺癌的影像学特征,可为乳腺癌的临床治疗提供更多有价值的信息。Objective:To explore the application values of ultrasound contrast combined with ultrasound elastography quantitative analysis of tissue diffusion in the diagnosis of breast cancer.Methods:From January 2019 to May 2020,148 cases of breast tumor patients were selected for diagnosis and treatment in our hospital.All patients were given ultrasound contrast combined with ultrasound elastography for quantitative analysis of tissue diffusion,and the imaging characteristics were recorded.Results:There were 32 cases were diagnosed as breast cancer by pathology(malignant group)and 116 cases were benign breast tumors(benign group)in the 148 cases.The benign group and malignant group compared were statistically significant differences in ultrasound lesion shape,margin,echo,microcalcification and other characteristics(P<0.05).The contrast enhancement mode and intensity of ultrasound contrast in the malignant group were significantly different from those in the benign group(P<0.05).The area under the curve(AUC),Peak intensity(PI),and wereh in slope(WIS)values of the malignant group were higher than those of the benign group,and the Time To Peak(TTP)values were lower than the benign group,and the contrast difference were statistically significant(P<0.05).The quantitative parameter of tissue diffusion in the malignant group were lower than the benign group in the blue area area ratio(%AREA),and the standard deviation(SD)and mean(MEAN)values were higher than the benign group(P<0.05).Conclusion:The application of ultrasound contrast combined with ultrasonic elastography quantitative analysis of tissue dispersion in the diagnosis of breast cancer is an economical,fast,non-invasive,and reproducible examination method that can quantitatively assess the imaging characteristics of breast cancer clinical treatment provides more valuable information.

关 键 词：超声造影 超声弹性成像组织弥散定量 乳腺癌 峰值强度 达峰时间 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]